CAS: 698-67-9; 4-Bromobenzamide

上下游产品

4-methoxycarbonylphenyl bromide 4-chlorobenzoyl chloride (4-bromo-benzoyl)-imidosulfurous acid dichloride N-Chlor-N'-p-brombenzoylacetamidin 1-(4-bromophenyl)-2-phenyl-ethan-1-one 4-bromo-benzoic acid-(trichlorophosphoranyliden-amide) 4-bromobenzenecarbonitrile (4-bromo-benzoyl)-amidophosphoryl chloride

4-溴苯腈置于cis-[mn(2,6-Bis(Di-Tert-Butylphosphinomethyl)Pyridine)(Co)2],水体系中,用 叔丁醇 作为反应溶剂,化学反应 24.0H,以88%的收率获得产物对溴苯甲胺
参考文献:锰-钳-催化腈水合,α-氘化和通过金属配体合作形成α-氘化酰胺
标题:锰-钳-催化腈水合,α-氘化和通过金属配体合作形成α-氘化酰胺
摘要:报道了一种简单有效的系统,用于腈的水合和 α-氘化以形成酰胺,α-氘化腈和 α-氘化酰胺,该系统由能够进行金属-配体合作的地球丰富锰的单钳络合物催化.该反应具有选择性并且可以耐受多种官能团,从而以中等至非常好的收率获得产物相应的酰胺.将溶剂从叔丁醇改为甲苯并使用 D 2 O 导致以高选择性形成 α-氘代腈.此外,可以一步直接从腈和 D 2 中获得 α-氘化酰胺o 在四氢呋喃中.初期机理研究表明,这些转变通过金属-配体协同途径促进了腈的活化,反应生成锰酮亚胺和烯酰胺钳络合物作为进一步转变的关键中间体.
DOI:10.1021/acscatal.1C01748

专利信息

专利号:US-4336383-A
优先权日:1980-05-07
标题:1-1-Binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid compounds, method of preparation and use thereof for the synthesis of asymmetric derivatives of 3,4,9,10-perylenetetracarboxylic acid, and for dyeing and printing of textile materials
发明人：VOROZHTSOV GEORGY N; MASANOVA NATALIA N; FELDBLJUM NIKOLAI B; ALEXEEV VASILY I; SHIGALEVSKY VADIM A; SOLOMATIN GEORGY G; SHULEPOVA OLGA I; KHAITUN GALINA G; GORDEEVA NADEZHDA V
权利人:VOROZHTSOV GEORGY N; MASANOVA NATALIA N; FELDBLJUM NIKOLAI B; ALEXEEV VASILY I; SHIGALEVSKY VADIM A; SOLOMATIN GEORGY G; SHULEPOVA OLGA I; KHAITUN GALINA G; GORDEEVA NADEZHDA V
摘要:1,1'-Binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid compounds having the following formula: ##STR1## wherein R 1 is hydrogen, halogen, or alkyl; when X is oxygen, Y is hydrogen, alkyl, a cycloalkyl, or an aryl containing at least one substituent from the group including: halogen, alkyl, or alkoxy, when X is nitrogen, Y is ##STR2## wherein R 2 is hydrogen, halogen, or alkyl; Y being linked to X with the formation of a benzimidazole cycle. n The method for preparing the compounds according to the present invention resides in the treatment of that 1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride with an alkali to give a corresponding salt which is condensed with orthophenylenediamines upon heating at reflux at a pH of from 6.3 to 6.8. The resulting benzimidazole-1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride having the formula: ##STR3## wherein R 1 is hydrogen, halogen, or alkyl, is isolated and condensed with an amine or ortho-phenylenediamines in an excess of the amine, in water or an organic solvent, followed by isolation of the desired product. n The compounds according to the present invention are employed for the synthesis of asymmetric compounds of 3,4,9,10-perylenetetracarboxylic acid, as well as for dyeing and printing of textile materials with the formation, on the material, of asymmetric compounds of 3,4,9,10-perylenetetracarboxylic acid having the following formula: ##STR4## wherein R 1 is hydrogen, halogen, or alkyl; when X is oxygen, Y is hydrogen, alkyl, cycloalkyl, or aryl containing at least one substituent from the group including; halogen, alkyl, or alkoxy, when X is nitrogen, Y is ##STR5## where R 2 is hydrogen, halogen, or alkyl; Y being linked with X to form a benzimidazole cycle. n The compounds according to the present invention dye textile materials to various shades of violet color.

专利号:US-8895741-B2
优先权日:2003-06-03
标 题:Process for the synthesis of biaryl oxazolidinones
发明人：WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG
权利人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG; MELINTA THERAPEUTICS INC
摘要:The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

专利号:US-5693792-A
优先权日:1992-02-18
标 题 :β-lactam and cephem compounds and processes for their production
发明人：TORII SHIGERU; TANAKA HIDEO; SASAOKA MITIO; SHIROI TAKASHI; KAMEYAMA YUTAKA
权利人:OTSUKA KAGAKU KK
摘要:The object of the invention is to provide a β-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics. n The β-lactam compound of the invention may be represented by the general formula ##STR1## wherein R 1 represents a protected amino group, for instance; R 2 represents hydrogen, for instance; R 3 represents hydrogen or a carboxy-protecting group; R 4 represents an aryl group which may be substituted; R 5 represents an alkenyl group which may be substituted, for instance. The 2-substituted methyl-3-cephem compound of the invention may be represented by the general formula ##STR2## wherein R 1 , R 2 and R 3 are as defined above; R 6 represents an aryl group which may be substituted.

专利号:US-7517895-B2
优先权日:2001-08-24
标题 :Synthetic diazonamides
发明人：HARRAN PATRICK G; LI JING; JEONG SUSAN
权利人:UNIV TEXAS
摘要:The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The application also discloses novel methods for synthesis of these compounds and methods of using these compounds.

专利号:US-12180188-B2
优先权日:2020-05-19
标题:Antifibrotic compounds and related methods
发明人：STEFANOVIC BRANKO; NEFZI ADEL
权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

专利号:US-7612064-B2
优先权日:2003-05-26
标题:Sulfopyrroles
发明人：EBERLE MARTIN; ERMERT PHILIPP; OBRECHT DANIEL; LACH FRANK; LUTHER ANATOL; BACHMANN FELIX; STREBEL ALLESSANDRO
权利人:TAKEDA PHARMACEUTICAL
摘要:The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.