专利号:US-2023313255-A1 优先权日:2020-07-15 标题:Massively Parallel Enzymatic Synthesis of Polynucleotides 发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER 权利人:DNA SCRIPT 摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.
专利号:US-2023183177-A1 优先权日:2020-04-24 标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds 发明人:GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK 权利人:PHARMAZELL GMBH 摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.
专利号:US-8101747-B2 优先权日:2009-03-31 标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 发明人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD 权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB 摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-4348370-A 优先权日:1980-01-08 标题:Ammonia synthesis with catalyst derived by heating on a support a salt selected from alkali metal, alkaline earth metal, iron and cobalt hexacyanocobaltates and hexacyanoruthenates 发明人:JOHNSON MARVIN M; TABLER DONALD C; NOWACK GERHARD P 权利人:PHILLIPS PETROLEUM CO 摘要:Synthesis of ammonia employing at least one salt selected from alkali metal-, an alkaline earth metal-, iron- and cobalt hexacyanocobaltate and hexacyanoruthenate on a suitable support and then heating the composition to provide it with suitable activity.
专利号:US-4309311-A 优先权日:1980-01-08 标 题 :Ammonia synthesis with catalyst derived by heating on a support a salt selected from alkali metal, alkaline earth metal, iron and cobalt hexacyanocobaltates and hexacyanoruthenates 发明人:JOHNSON MARVIN M; TABLER DONALD C; NOWACK GERHARD P 权利人:PHILLIPS PETROLEUM CO 摘要:Synthesis of ammonia employing at least one salt selected from alkali metal-, an alkaline earth metal-, iron- and cobalt hexacyanocobaltate and hexacyanoruthenate on a suitable support and then heating the composition to provide it with suitable activity.
专利号:US-5321143-A 优先权日:1988-05-26 标题 :Ruthenium-catalyzed production of cyclic sulfates 发明人:SHARPLESS K BARRY; GAO YUN 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.
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合成参考文献
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