CAS: 82230-93-1; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-14-Ethyl-7,12,13-Trihydroxy-4-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3-(Hydroxymethyl)-5,7,9,11,13-Pentamethyloxacyclotetradecane-2,10-Dione

该化合物是一个复杂的有机化合物,其特点是分子结构复杂,包括多种氢氧基,甲氧基和二甲基氨基动物,具有独特的三环曲贸易干柱,表明环球醚结构有助于其稳定性和潜在的生物活动,各种替代成分,如氢氧化物和甲氧化合物组的存在表明,它可能在极地溶剂中表现出严重的溶解性,并可能与生物系统发生相互作用,从而可能影响药理特性,其结构复杂性还可能表明其在药用化学中或作为有机合成合成的合成中间体的潜在应用,然而,有关其反应性,稳定性和生物影响的具体细节需要通过实验研究作进一步调查.

英文名称(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-14-Ethyl-7,12,13-Trihydroxy-4-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3-(Hydroxymethyl)-5,7,9,11,13-Pentamethyloxacyclotetradecane-2,10-Dione
中文名称16-羟基红霉素
IUPAC名称(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3-(hydroxymethyl)-5,7,9,11,13-pentamethyloxacyclotetradecane-2,10-dione
其它别名16-Hydroxyerythromycin; Erythromycin F; Erythromycin F【erythromycin Impurity A (Ep) 】; Erythromycin Impurity 1; Erythromycin Ep Impurity A/(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-Ribo-Hexopyranosyl)Oxy]-14-Ethyl-7,12,13-Trihydroxy-3-(Hydroxymethyl)-5,7,9,11,13-Pentamethyl-6-[[3,4,6-Trideoxy-3-(Dimethylamino)-β-D-Xylo-Hexopyrano; Erythromycin Impurity 1(Erythromycin Ep Impurity A); Erythromycin Impurit A:(Erythromycin F); Erythromycin, 16-Hydroxy-
CAS编号82230-93-1
FDA UNII编号:NM325T380N
分子式:C37H67NO14
分子量:749.94
产品CID: 1813684
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: DZCOSWPAQGXWKC-SGOZKCKASA-N
DZCOSWPAQGXWKC-TZIZHKBZSA-N…
计算化学: 氢键受体数15.0氢键供体数6.0可旋转键数8.0

MSDS等安全信息

警示词warning
危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

合成工艺路线路线简述

红霉素置于suwannee River Natural Organic Matter体系中,用水作为反应溶剂,化学反应生成 Anhydroerythromycin,红霉素c,16-羟基红霉素,(3S,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyloxan-2-Yl]Oxy-14-Ethyl-7,12,13-Trihydroxy-4-[(2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyloxan-2-Yl]Oxy-5,7,9,11,13-Pentamethyl-2,10-Dioxo-Oxacyclotetradecane-3-Carbaldehyde,,
参考文献:Chronic Toxic Effects Of Erythromycin And Its Photodegradation Products On Microalgae Chlorella Pyrenoidosa
标题:Chronic Toxic Effects Of Erythromycin And Its Photodegradation Products On Microalgae Chlorella Pyrenoidosa
摘要:
DOI:10.1016/j.Aquatox.2024.106922

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-02064608-A1
优先权日:2000-11-29
标题:Synthesis and separation of optically active isomers of erythromycin and their biological actions
发明人：SOMBERG JOHN C; RANADE VASANT
权利人:ACADEMIC PHARM INC; SOMBERG JOHN C; RANADE VASANT
摘要:The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.

专利号:EP-1339731-A1
优先权日:2000-11-29
标题:Synthesis and separation of optically active isomers of erythromycin and their biological actions