4-<(2R,5S)-2,5-Dihydro-2-Isopropyl-3,6-Dimethoxy-5-Pyrazinyl>Butyronitrile置于盐酸,Lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 1.5H,反应生成L-赖氨酸盐酸盐 参考文献:Raap,J.; Wielen,C. M. Van Der; Lugtenburg,J.,Recueil Des Travaux Chimiques Des Pays-Bas,1990,Vol. 109,# 4,P. 277-286 标题:Raap,J.; Wielen,C. M. Van Der; Lugtenburg,J.,Recueil Des Travaux Chimiques Des Pays-Bas,1990,Vol. 109,# 4,P. 277-286
专利号:US-6410643-B1 优先权日:2000-03-09 标题 :Solid phase synthesis method and reagent 发明人:SWANSON MELVIN J 权利人:SURMODICS INC 摘要:A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.
专利号:US-10633398-B2 优先权日:2014-06-18 标 题 :Synthesis of zinc-lysine complex from zinc chloride 发明人:NAWROCKI SHIRI; SUBRAMANYAM RAVI; PAN LONG 权利人:COLGATE PALMOLIVE CO 摘要:The disclosure provides an improved synthesis for a zinc-lysine complex having the formula [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − , in which zinc chloride is reacted with lysine, in aqueous solution. The disclosure also provides oral care and personal care compositions comprising the complex prepared by the synthesis, and methods of using these complexes and compositions.
专利号:US-9169502-B2 优先权日:2010-06-15 标题 :Method of producing L-lysine using a Corynebacterium glutamicum microorganism 发明人:WITTMANN CHRISTOPH; BECKER JUDITH 权利人:WITTMANN CHRISTOPH; BECKER JUDITH; PAIK KWANG IND CO LTD 摘要:The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.
专利号:US-8367819-B2 优先权日:2004-06-10 标 题:Synthesis of caprolactam from lysine 发明人:FROST JOHN W 权利人:UNIV MICHIGAN STATE; FROST JOHN W 摘要:In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-εcaprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.
专利号:US-11718864-B2 优先权日:2015-09-23 标 题 :Cells and method of cell culture 发明人:HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY 权利人:PFIZER 摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.
专利号:US-10882811-B2 优先权日:2016-12-23 标题 :Synthesis of lysine acetylsalicylate glycine particles 发明人:NOCKER KARLHEINZ; ZUHSE RALF; OSTROVSKYI DMYTRO 权利人:ASPIAIR GMBH 摘要:The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate.glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providing an aqueous solution of lysine; c) combining the solutions of step a) and b) to form a mixture; d) optionally stirring the mixture; e) adding acetone to the mixture; f) incubating the mixture, to allow the formation of a acetylsalicylic acid lysinate product; g) isolating the acetylsalicylic acid lysinate product; wherein acetylsalicylic acid is used in excess compared to lysine and wherein no seed crystals are added to the mixture; and optionally the following further steps: h) providing a recrystallized glycine; wherein the glycine has been recrystallized with the following steps: h1) dissolving glycine in water; h2) adding acetone to the glycine solution; h3) stirring the mixture until a precipitate is obtained; i) combining the recrystallized glycine of step h) with the acetylsalicylic acid lysinate product of step g) to obtain lysine acetylsalicylate.glycine (LASAG) particles.
参考标题:α-N-Protected Dipeptide Acids: A Simple And Efficient Synthesis Via The Easily Accessible Mixed Anhydride Method Using Free Amino Acids In Dmso And Tetrabutylammonium Hydroxide 作者:G. Verardo,A. Gorassini |发布日期:2013.5 摘要:To Find Simple And Efficient Methods For Their Synthesis. For This Reason, We Have Investigated The Synthesis Of α‐n‐protected Dipeptide Acids By Reacting The Easily Accessible Mixed Anhydride Of α‐n‐protected Amino Acids With Free Amino Acids Under Different Reaction Conditions. The Combination Of Tba‐oh And Dmso Has Been Found To Be The Best To Overcome The Low Solubility Of Amino Acids In Organic
合成参考文献
摘要:Journal of Pharmaceutical Sciences., 62(49), 1973 [] 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 32(Suppl. 4):41-64, 2013 参考文献:10.1007/s004240050920 摘要:Dijkink L, Hartog A, Deen PMT, van Os CH, Bindels RJM. Time-dependent regulation by aldosterone of the amiloride-sensitive Na + channel in rabbit kidney. Pflgers Archiv European Journal of Physiology. 1999 Jul 19;438(3):354–60. doi: 10.1007/s004240050920. 参考文献:10.1007/s002800050962 摘要:Vasandani VM, Burris JA, Sung C. Reversible nephrotoxicity of onconase and effect of lysine pH on renal onconase uptake. Cancer Chemotherapy and Pharmacology. 1999 Jun 17;44(2):164–9. doi: 10.1007/s002800050962.