CAS: 1064-48-8; Sodium 4-Amino-5-Hydroxy-3-((4-Nitrophenyl)Diazenyl)-6-(Phenyldiazenyl)Naphthalene-2,7-Disulfonate

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CAS号64-18-6 甲酸 | CAS号144-62-7 草酸 | CAS号64-19-7 冰醋酸

专利信息

专利号:US-6660305-B1
优先权日:1998-07-28
标题 :Composition for stimulating the synthesis of the melanic pigment and process for obtaining it
发明人：CAO CARLOS M MIYARES
权利人:CT DE HISTOTERAPIA PLACENTARIA
摘要:This invention relates to the field of human medicine, more specifically to dermatology, and in particular to a composition developed for the stimulation of the synthesis of the melanic pigment of the skin, therefore useful for the treatment of vitiligo. The technical goal of this invention is to provide a composition of natural origin useful in the treatment of vitiligo that has no toxic effects and no relapse. The composition obtained stimulates the synthesis of the melanic pigment of the skin and the reproduction of melanocytes, as demonstrated through pharmacological tests to which the composition was subjected, causing no serious secondary reactions at all, as demonstrated in the toxicological, teratological and clinical tests performed. The resulting product can easily be obtained and applied, repigmentation begins rapidly after initiating the treatment, and the effect is irreversible. The color acquired is identical to the color of the normal skin areas of the patient, but these areas do not further increase the intensity of their coloration after the product has been applied. The product can also be used for the treatment of any depigmentation process of the skin, for example, that caused by burns.

专利号:WO-2024199465-A1
优先权日:2023-03-30
标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification
发明人：CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI
权利人:UNIV HONG KONG CHINESE
摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6600029-B1
优先权日:1995-12-19
标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
发明人：SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

专利号:US-6713607-B2
优先权日:1994-03-08
标 题:Effector proteins of Rapamycin
发明人：CAGGIANO THOMAS J; CHEN YANQIU; FAILLI AMEDEO A; MOLNAR-KIMBER KATHERINE L; NAKANISHI KOJI
权利人:WYETH CORP; UNIV COLUMBIA
摘要:This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.

专利号:US-5668295-A
优先权日:1990-11-14
标 题 :Protein involved in nicotine synthesis, DNA encoding, and use of sense and antisense DNAs corresponding thereto to affect nicotine content in transgenic tobacco cells and plants
发明人：WAHAB SAMIR Z; MALIK VEDPAL S
权利人:PHILIP MORRIS INC
摘要:Nicotine acid sequences encoding a tobacco protein involved in nicotine synthesis are described. These sequences, when inserted in to sense or anti-sense orientation, affect nicotine synthesis in transgenic tobacco plants.