CAS: 119-84-6; Chroman-2-One

该化合物是一个循环期酯,分子分子式C9H8O2,由氢化法制成,无色可粉黄液,含有甜美,香草味的气味,经常用作香味成分和香味剂,其主要优点包括高度稳定性,低挥发性,与各种化妆品和食品应用相容.二氢丙烯作为有机合成的中间体,因其在香水中传递温暖,类似丙丙烯的笔,受到重视,其无毒性特征和温度使其适合用于个人护理产品和工业配方的遮罩剂.

结构式图片

相似化合物

5631-67-4 20920-98-3 32560-26-2

欧盟法规

REACH注册ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册

上下游产品

benzofurane-3-carboxylic acid 3,3-Dimethylacryloyl chloride 5-methoxyresorcinol 2-ox°Chroman-3-carboxylic acid4-(2-hydroxyphenyl)-2-methyl-2-butanol 3-ethyl-1-(2-hydroxyphenyl)-3-pentanol 6-bromo-2H-chromen-2-one 4-hydroxy-2,3-dihydroindan-1-one

合成工艺路线路线简述

  • 合成目标产物 Dihydrocoumarin 主要起始原料 1-Indanone
  • (文献来源)合成步骤主要原料 1-Indanone
苯并呋喃-3-羧酸置于sodium Hydroxide,Aluminum Nickel体系中,化学反应生成氢化肉桂酸内酯
参考文献:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali. Part Viii. Hydrogenolysis Of Furan Derivatives1
标题:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali. Part Viii. Hydrogenolysis Of Furan Derivatives1
摘要:
Doi:10.1021/jo01142A015

海关参考信息

专利信息


专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-11401235-B2
优先权日:2015-09-22
标 题 :Synthesis of terphenyl compounds
发明人:KAYE ANTHONY; QUAZI NURUL; FEAST GEORGE; LAKSHMAN MARSHNIL
权利人:VECTUS BIOSYSTEMS LTD
摘要:The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I n nor intermediates thereof.

专利号:US-8987493-B2
优先权日:2010-05-20
标题 :Process for synthesis of silane dipeptide analogs
发明人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN
权利人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN; Temple University—Of the Commonwealth System of Higher Education
摘要:The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the dilithium salt of a substituted 3-hydroxypropylsilanol, and reacting the solution of the dilithium salt of the substituted 3-hydroxypropylsilanol with a substituted enamine.

专利号:US-10745354-B2
优先权日:2017-11-01
标题 :Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
发明人:STOLTZ BRIAN M; NGAMNITHIPORN AURAPAT; JETTE CARINA I; BACHMAN SHOSHANA; VIRGIL SCOTT C; LACKNER SEBASTIAN
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

专利号:US-2004044225-A1
优先权日:2001-06-01
标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives
发明人:KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK
摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.

专利号:US-9981935-B2
优先权日:2013-07-05
标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
发明人:MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.
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✅ COA系统入驻 | 共享模式

主要参考文献


1: Xie CC, Zhang BP, Wang HN, Li WY, Cai ZL, He Y, Ji K, Chen JJ. Flavoring agent dihydrocoumarin alleviates IgE-mediated mast cell activation and allergic inflammation. Food Funct. 2022 Mar 21;13(6):3621-3631. doi: 10.1039/d2fo00190j. 18(12):2655. doi: 10.3390/ijms18122655.
3: Yang H, Zhou S, Wu L, Wang L. Interference of Dihydrocoumarin with Hormone Transduction and Phenylpropanoid Biosynthesis Inhibits Barnyardgrass (Echinochloa crus-galli) Root Growth. Plants (Basel). 2022 Sep 26;11(19):2505. doi: 10.3390/plants11192505.
4: Hou HM, Jiang F, Zhang GL, Wang JY, Zhu YH, Liu XY. Inhibition of Hafnia alvei H4 Biofilm Formation by the Food Additive Dihydrocoumarin. J Food Prot. 2017 May 1;80(5):842-847. doi: 10.4315/0362-028X.JFP-16-460. 156 Suppl

合成参考文献


摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2009) 46, 87.
摘要:Merino, P., Science of Synthesis, (2010) 45, 306.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 228.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 162.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 229.
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