2,4-Bis-Ethoxycarbonyloxy-6-Pentyl-Benzoic Acid置于ammonium Hydroxide,乙醚体系中,化学反应生成 2,4-二羟基-6-戊基苯甲酸甲酯 参考文献:Medicinal Plants Used By Latino Healers For Women's Health Conditions In New York City 标题:Medicinal Plants Used By Latino Healers For Women's Health Conditions In New York City 摘要:This Paper Examines Rite Use Of Medicinal Plants By Latino Healers In New York City To Treat Various,Women'S Illnesses. Eight Latino Healers Collaborated On The Study Through Consultations With Female Patients Who Had One Of The Following Conditions As Diagnosed By Biomedically Trained Physicians: Uterine Fibroids,Hot Flashes,,Menorrhagia,Or Endometrosis. The Study Identified A Total Of 67 Plant Species Prescribed By The Healers In The Form Of Mixtures Or As Individual Plants. Voucher Specimens Were Collected From Local Botanicas And Identified By Specialists At The New. York Botanical Garden. Studies Of Immigrant Traditional Healers And The Plants They Use In An Urban Setting Ran Provide Interesting Ethnobotanical Data And Information To Assist In Diagnosing Conditions And Contributing To Treatment Of Patients From Latino As,Well As Non-Latino Communities. DOI:10.1007/bf02864786
专利号:US-10807931-B2 优先权日:2017-08-16 标 题:Synthesis of phytocannabinoids including a decarboxylation step 发明人:REEKIE TRISTAN; SCOTT MICHAEL; KASSIOU MICHAEL 权利人:UNIV SYDNEY 摘要:Method for decarboxylating a carboxylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C 1 -C 5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C 2 -C 8 alkene, or a substituted or unsubstituted C 2 -C 8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes heating a reaction mixture comprising the carboxylated phytocannabinoid compound and a polar aprotic solvent in the presence of a LiCl for a time sufficient to decarboxylate at least a portion of the carboxylated phytocannabinoid compounds and form the phytocannabinoid compound.
专利号:US-2021163438-A1 优先权日:2017-08-16 标题 :Synthesis of phytocannabinoids including a demethylation step 发明人:REEKIE TRISTAN; SCOTT MICHAEL; KASSIOU MICHAEL 权利人:UNIV SYDNEY 摘要:A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.
专利号:US-5342971-A 优先权日:1992-12-29 标 题 :Process for the preparation of dibenzo[b,d]pyrans 发明人:HERLT TONY JOHN; MACDONALD PETER LINDSAY; RICKARDS RODNEY WARREN 权利人:ALCO CHEMICALS LTD; UNIV AUSTRALIAN 摘要:Dibenzo[b,d]pyrans are prepared by heating a dihydroxybenzoic acid derivative in the presence of a Lewis acid catalyst and an inert non-polar solvent in which the dihydroxybenzoic acid is soluble but in which the Lewis acid catalyst is insoluble or very slightly soluble. A typical embodiment involves the preparation of intermediates useful in the synthesis of dronabinol and related dibenzo[b,d]pyrans.
专利号:JP-2020530855-A 优先权日:2017-08-16 标题:Synthesis of phytocannabinoids involving demethylation steps
专利号:WO-2019033164-A1 优先权日:2017-08-16 标题:SYNTHESIS OF PHYTOCANNABINOIDS COMPRISING A DEM ETHYLATION STEP
专利号:WO-2019033168-A1 优先权日:2017-08-16 标题 :SYNTHESIS OF PHYTOCANNABINOIDS COMPRISING A DECARBOXYLATION STAGE
参考标题: Synthesis Of (+)-Cannabinoids And Their Therapeutic Effects Synthèse De (+)-Cannabinoïdes Et Effets Thérapeutiques Associés 摘要:The Present Invention Relates To A Method Of Producing A Compound Of Formula (I) Or A Salt Of A Compound Of Formula (I). The Invention Also Relates To A Compound Of Formula (I) Or A Salt Of A Compound Of Formula (I) For Use In A Therapeutic Method To Achieve One Or More Therapeutic Effects As Well As For Use In The Treatment And/or Prevention Of Certain Diseases. Furthermore, The Invention Provides A Pharmaceutical Composition Comprising One Or More Compound(S) Of Formula (I) Or Salt(S) Of Compound(S) Of Formula (I).
合成参考文献
参考文献:10.1515/znc-2008-1-206 摘要:Gianini AS, Marques MR, Carvalho NC, Honda NK. Activities of 2,4-dihydroxy-6-n-pentylbenzoic acid derivatives. Z Naturforsch C J Biosci. 2008 Jan;63(1-2):29–34. doi: 10.1515/znc-2008-1-206. 摘要:Yoon, T. P.; Jacobsen, E. N., Science of Synthesis, (2007) 20, 1295.