CAS: 6084-58-8; O-Isobutylhydroxylamine Hydrochloride

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参考文献:Synthesis And Fungicidal Activity Of Macrolactams And Macrolactones With An Oxime Ether Side Chain
标题:Synthesis And Fungicidal Activity Of Macrolactams And Macrolactones With An Oxime Ether Side Chain
摘要:Three Series Of Novel Macrolactams And Macrolactones-12-Alkoxyimino-Tetradecanlactam,12-Alkoxyiminopentadecanlactam,And 12-Alkoxyiminodecanlactone Derivatives (7A,7B,And 7C)-Were Synthesized From Corresponding 12-Oxomacrolactams And 12-Oxomacrolactone. Their Structures Were Confirmed By H-1 NMR And Elemental Analysis. The Z And E Isomers Of 7A And 7B Were Separated,And Their Configurations Were Determined By H-1 NMR. These Compounds Showed Fair To Excellent Fungicidal Activities Against Rhizoctonia Solani Kuhn. It Is Interesting That The Z And E Isomers Of Most Of The Compounds Have Quite Different Fungicidal Activities. The Fact That The Compounds Have A Gradual Increase Of Fungicidal Activity In The Order Of 7A,7C,And 7B Indicated That The Macrocyclic Derivatives With A Hydrogen-Bonding Acceptor (=n-O-) And A Hydrogen-Bonding Donor (-Conh-) On The Ring,And A Three Methylenes Distance (Ch2Ch2Ch2) Between These Two Functional Groups,Exhibited The Best Fungicidal Activity. The Bioassay Also Showed That 7B Not Only Has Good Fungicidal Activity But Also May Have A Broad Spectrum Of Fungicidal Activities.
DOI:10.1021/jf072733+

专利信息

专利号:US-5510511-A
优先权日:1992-01-14
标 题 :Process for preparing N,O-dialkylhydroxylamine, its salts or intermediates in their synthesis
发明人：INOKI SATOSHI; TAKESUE MITSUYUKI; HASHIMOTO ISAO; KIHARA NORIAKI; SUGI KIYOAKI
权利人:MITSUI PETROCHEMICAL IND
摘要:A process for preparing N,O-dialkylhydroxycarbamic acid ester which comprises reacting hydroxylamine or its salt with dihydrocarbyl carbonate in the presence of a basic compound to prepare hydroxycarbamic acid ester and subsequently alkylating this compound with an alkylating agent; a process for recovering N,O-dialkylhydroxycarbamic acid ester which comprises azeotropically distilling the ester with water from a solution containing the ester; a process for preparing N,O-dialkylhydroxylamine which comprises hydrolyzing N,O-dialkylhydroxycarbamic acid ester in an aqueous solution or a hydrous solvent in the presence of an alkali; a process for purifying N,O-dialkylhydroxylamine hydrochloride which comprises adding aldehyde or ketone to a solution of N,O-dialkylhydroxylamine hydrochloride containing O-alkylhydroxylamine hydrochloride as impurities to convert the O-alkylhydroxylamine hydrochloride into O-alkyl aldoxime or O-alkyl ketoxime and subsequently separating the N,O-dialkylhydroxylamine hydrochloride from the reaction system; and a process for separating N,O-dialkylhydroxylamine hydrochloride which comprises (i) adding benzene or alkylated benzene to an aqueous solution containing N,O-dialkylhydroxylamine hydrochloride, azeotropically removing water or a hydrochloride solution, and, subsequently (ii)adding alcohol thereto to obtain N,O-dialkylhydroxylamine hydrochloride in the form of crystal.

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