CAS: 6258-66-8; 4-Chlorobenzylmercaptan

上下游产品

4-chlorobenzyl dimethylcarbamodithioate 1-Chloro-4-(chloromethyl)benzene thiourea ethanol 2-(4-chloro-benzylsulfanyl)-ethylamine (4-chloro-benzyl)-[2]thienylmethyl sulfide S-(4-chlorobenzyl)benzothioate 1,3-bis-(4-chloro-benzylsulfanyl)-propane

4-氯氯苄置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 3.33H,反应生成 4-氯苄硫醇
参考文献:反式(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃碳硫酰胺1-氧化物(rp 49356)及其类似物的合成和生物活性:一类新型的钾通道开放剂.
标题:反式(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃碳硫酰胺1-氧化物(rp 49356)及其类似物的合成和生物活性:一类新型的钾通道开放剂.
摘要:报道了反式-(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃氨基甲磺酰胺+++ E 1-氧化物(8A,Rp 49356)和类似物的合成和生物活性.这些化合物构成k(+)通道开放剂的新结构类.讨论了吡啶基,硫代酰胺和硫杂环上的变化对体外k(+)通道开放反应性的影响.为了活性,优选3-吡啶基或3-喹啉基,小的n-烷基硫代酰胺官能团和氧化亚砜环,其中亚砜与硫代酰胺具有反式关系.选择的化合物在降压麻醉的大鼠中静脉内测试降压作用,其活性反映了其体外k(+)通道的开放活性.
DOI:10.1021/jm00098A004

专利信息

专利号:US-7273933-B1
优先权日:1998-02-26
标 题 :Methods for synthesis of oligonucleotides
发明人：KROTZ ACHIM H; RAVIKUMAR VASULINGA T
权利人:ISIS PHARMACEUTICALS INC
摘要:Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated aromatic solvents, halogenated alkyl aromatic solvents, or aromatic ether solvents to achieve deprotection of protected hydroxyl groups.

专利号:US-5714597-A
优先权日:1994-07-07
标题:Use of carbocation scavenger during oligonucleotide synthesis
发明人：RAVIKUMAR VASULINGA; ANDRADE MARK; MULVEY DENNIS; COLE DOUGLAS L
权利人:ISIS PHARMACEUTICALS INC
摘要:During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.

专利号:US-11970694-B2
优先权日:2009-10-22
标题 :Rapid display method in translational synthesis of peptide
发明人：KASHIWAGI KENJI; REID PATRICK
权利人:PEPTIDREAM INC
摘要:Provided are linkers suitable for preparing a conjugate of a nucleic acid and a peptide as a translation product thereof in a reconstituted cell-free translation system in genotype-phenotype mapping (display methods), said linkers comprising a single-stranded structure region having a side chain base pairing with the base at the 3′-end of an mRNA at one end and a peptidyl acceptor region containing an amino acid attached to an oligo RNA consisting of a nucleotide sequence of ACCA via an ester bond at the other end, characterized in that the ester bond is formed by using an artificial RNA catalyst. Also provided are display methods using [mRNA]-[linker]-[peptide] conjugates assembled via such linkers.

专利号:WO-0038685-A1
优先权日:1998-12-30
标 题 :Solution phase synthesis of compounds including amine alcohol functionality
发明人：DRESSMAN BRUCE A; GODFREY ALEXANDER G
权利人:LILLY CO ELI; DRESSMAN BRUCE A; GODFREY ALEXANDER G
摘要:This invention relates to a process for producing a plurality of compounds of formula (I): The invention is also directed to a reaction vessel on which a plurality of compounds of the same formula are physically separated from each other. The invention is also directed to a method of optimizing the biological activity of a compound of the same formula. The process for producing the compounds is ideal for generating libraries of compounds for high throughput screening. The invention also provides a library of above compounds physically separated from one another in a reaction vessel. This library is useful for optimizing the activity of therapeutically useful compounds.

专利号:US-5331096-A
优先权日:1992-04-01
标题 :2- and 3-sulfur derivatives of 1,5-iminosugars
发明人：KOSZYK FRANCIS J; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-5342951-A
优先权日:1992-04-01
标题:2- and 3-sulfur derivatives of 1,5-iminosugars
发明人：KOSZYK FRANCIS J; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.