专利号:US-9925504-B2 优先权日:2004-03-31 标 题 :Compartmentalised combinatorial chemistry by microfluidic control 发明人:GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME 权利人:GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME; HARVARD COLLEGE; MEDICAL RES COUNCIL 摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.
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合成参考文献
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