CAS: 913733-27-4; Fmoc-N-Me-Arg(Pbf)-Oh

该化合物是一种受保护的氨酸衍生物,通常用于peptide合成中."Fmoc"(9-氟戊基甲基碳酸基)组群是氨基功能的保护组,允许在pepttide组装过程中有选择性的反应."N-Me"表示,链侧链的氮原子是甲基的,可以影响化合物的溶性与反应."Arg"是指anjinine,一种氨酸,其特征是其在生理pH中具有积极充电的侧链,有助于其在蛋白质结构和功能中的作用."(bf)"表示在亚氏氨基苯基苯乙烯组中存在2,2,4,4,4,6-五溴二苯醚(Pbf)).该组保护组在合成过程中稳定分子并防止不想要的反应.总体而言,Fmoco-N-ME-Arg(pbf)(HH)-HHE)在ppepdidic化学领域很有价值,因为它有能力促进复杂的peptides合成,同时保持功能组的完整性.

英文名称Fmoc-N-Me-Arg(Pbf)-Oh
中文名称FMOC-N-甲基-PBF-L-精氨酸
IUPAC名称N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N2-methyl-Nw-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine
其它别名(S,E)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)(Methyl)Amino)-5-((Amino(2,2,4,6,7-Pentamethyl-2,3-Dihydrobenzofuran-5-Sulfonamido)Methylene)Amino)Pentanoic Acid; (2S)-2-[9H-Fluoren-9-Ylmethoxycarbonyl(Methyl)Amino]-5-[[n-[(2,2,4,6,7-Pentamethy
CAS编号913733-27-4
MFCD编号:MFCD02094401
分子式:C35H42N4O7S
分子量:662.8
产品CID: 1949262
产品分类生物化工 → 多肽

相似结构搜索
InChIKey: MEGKXARLCPKZHJ-LJAQVGFWSA-N
AXPMRTFXKPJFIB-PMERELPUSA-N…
计算化学: 氢键受体数8.0氢键供体数3.0可旋转键数12.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319-H335
防范说明P280-P305+P351+P338-P321

合成工艺路线路线简述

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-10407468-B2
优先权日:2016-03-23
标题 :Methods for synthesizing Î±4Î²7 peptide antagonists
发明人：BHANDARI ASHOK; MANTHATI SURESH KUMAR; MEHROTRA MUKUND M; ANANDAN SAMPATH-KUMAR; PATEL DINESH V
权利人:PROTAGONIST THERAPEUTICS INC
摘要:The present invention provides methods of making Î±4Î²7 peptide monomer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.

专利号:US-2022185846-A1
优先权日:2019-03-28
标题:Methods for synthesizing beta-homoamino acids
发明人：MANTHATI SURESH KUMAR; BHANDARI ASHOK; MASJEDIZADEH MOHAMMAD REZA
权利人:PROTAGONIST THERAPEUTICS INC
摘要:Methods of making Î²-homoamino acids as intermediate for synthesis of peptide monmer and dimer Î±4Î²7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.

专利号:CN-115925790-A
优先权日:2016-03-23
标题:Method for the synthesis of Î±4Î²7 peptide antagonists