CAS: 95-01-2; 2,4-Dihydroxybenzaldehyde

上下游产品

2-羟基-4-甲氧基苯甲醛 2-Hydroxy-4-Methoxybenzaldehyde 673-22-3
水杨醛 Salicylaldehyde 90-02-8
2,4-二羟基苯甲酸 4-Hydroxysalicylic Acid 89-86-1
2,4-Dihydroxy-Benzaldehyde Imine 5660-21-9
2,4-Diprenyloxybenzaldehyde 62417-02-1
3-甲酰基-2,6-二羟基-苯甲酸 3-Formyl-2,6-Dihydroxy-Benzoic Acid 859964-44-6

2,4-二羟基苯甲酸置于glycerol-3-Phosphate Dehydrogenase,葡萄糖,Nadp+,Nocardia Pptase,Segniliparus Car,5'-三磷酸腺苷,辅酶 A,Magnesium Chloride体系中,用 二甲基亚砜 作为反应溶剂,化学反应 16.0H,反应生成 2,4-二羟基苯甲醛
参考文献:Exploring The Synthetic Applicability Of A New Carboxylic Acid Reductase From Segniliparus Rotundus Dsm 44985
标题:Exploring The Synthetic Applicability Of A New Carboxylic Acid Reductase From Segniliparus Rotundus Dsm 44985
摘要:A New Carboxylic Acid Reductase (Car) Gene From Segniliparus Rotundus Dsm 44985 Was Overexpressed In Escherichia Colt. The Recombinant Enzyme Exhibited High Activity Toward A Variety Of Aromatic And Aliphatic Carboxylic Acids. Especially,It Effectively Reduced 4-Hydroxybenzoic Acid (8A) And 4-Nitrobenzoic Acid (19A),Toward Which The Known Nocardia Car Exhibited No Or Little Activity. The Recombinant E. Colt Cells Co-Expressing The Segniliparus Car And Nocardia Pptase Genes Catalyzed The Reductions Of Vanillic Acid (20A) And 3,4-Dihydroxyphenylacetic Acid (25A) To Give Vanillyl Alcohol (20C) And 3-Hydroxytyrosol (25C) With High Yield,Respectively. The Endogenous Aldehyde Reductases Of E. Coli Should Be Responsible For The Further Reduction Of The Produced Aldehydes. These Results Demonstrated That Segniliparus Car Was A Useful Addition To The Biocatalyst Tool-Box For The Reduction Of Carboxylic Acids And Might Find Applications In The Synthesis Of Valuable Bio-Based Chemicals From Renewable Resources. (C) 2015 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Molcatb.2015.01.014

专利信息

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-10561681-B2
优先权日:2016-07-21
标题 :Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents
发明人：ARSENJANS PAVELS; VASILJEVA JELENA; DOMRACHEVA ILONA; SHESTAKOVA IRINA; KALVINS IVARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.

专利号:US-2009099061-A1
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
发明人：FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

专利号:US-9284348-B2
优先权日:2005-09-20
标 题:Method for synthesis of peptide using a carrier
发明人：CHIBA KAZUHIRO; KIM SHOKAKU; KONO YUSUKE
权利人:JITSUBO CO LTD
摘要:Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase after the completion of the reaction readily, enable the separated compound to be evaluated by structural analysis or the like while the compound being bound to the carrier, and enable the compound to be separated from the carrier readily. A carrier for separation which has a reaction site capable of reacting with other compound on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.

专利号:US-9227948-B2
优先权日:2012-06-19
标题:Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives
发明人：MUDDASANI PULLA REDDY; CHINTALAPUDI MANIKUMAR; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I the above Formula I, XII, XIII, XV, wherein R 1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R 2 is C 1 -C 6 alkyl. 2,4-Dihydroxy-3-methylbenzaldehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry. Compounds of formula-I are key intermediates in the synthesis of ecteinascidines like trabectedin.

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.