2,5-二甲基苯甲酸置于水体系中,用 水 作为反应溶剂,化学反应 6.0H,以41%的收率获得产物2,5-二甲基苯酚 参考文献:Process For Preparing An Aryl Formate And An Aromatic Carboxylic Acid 标题:Process For Preparing An Aryl Formate And An Aromatic Carboxylic Acid 摘要:通过在有机溶剂中氧化芳香醛,使用在反应系统中由甲酸和过氧化氢反应生成的过氧甲酸反应生成芳酸酯的方法.可选的方法包括第二步,将芳酸酯分解为酚化合物.这第二步可通过在液相中在碱金属化合物存在下,以110至350oc热分解芳酸酯为酚化合物和一氧化碳来实现.
专利号:US-9815809-B2 优先权日:2013-07-05 标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols 发明人:LETINOIS ULLA; NETSCHER THOMAS 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.
专利号:WO-2025132814-A1 优先权日:2023-12-21 标 题:Novel synthesis of methyl-2-fluoroacrylate 发明人:BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN 权利人:VIFOR INT AG 摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).
专利号:US-2023416178-A1 优先权日:2020-11-09 标题:Formation of p-alkylphenols based on intermolecular reaction of ethyne with 2-alkylfurans in the presence of gold(i) complexes 发明人:ACKERMANN-MAURER STEPHAN; BONRATH WERNER; LETINOIS ULLA; NETSCHER THOMAS; SCHUETZ JAN 权利人:DSM IP ASSETS BV 摘要:The present invention relates to the synthesis of p-alkylphenols and of 2,6-dimethyl-4-alkyl phenol from 2-alkylfurans with acetylene in the presence of a gold(I) complex as well as to 2,3,6 trimethylhydroquinone.
专利号:US-10815178-B2 优先权日:2015-12-21 标 题:Intermolecular reaction of propargyl ethers with dimethylfuran in the presence of gold(I) complexes 发明人:LETINOIS ULLA; ACKERMANN STEPHAN; MEDLOCK JONATHAN ALAN; LEHMANN HAJO 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.
专利号:US-5670465-A 优先权日:1993-01-08 标题 :Preparation of p-fuchsones and synthesis of p-dihydroxylated aromatic compounds therefrom 发明人:COSTANTINI MICHEL; MANAUT DANIEL; MICHELET DANIEL 权利人:RHONE POULENC CHIMIE 摘要:p-Dihydroxylated aromatic compounds are prepared via the oxidation of p-fuchsones, the latter advantageously being synthesized by reacting a phenolic compound having at least one hydrogen atom in the para-position to the hydroxyl function with a non-enolizable ketonic compound, in the presence of a catalytically effective amount of an acid catalyst and, optionally, a cocatalytically effective amount of an ionizable sulfur-containing compound.
专利号:US-8653282-B2 优先权日:2007-10-18 标 题:Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein 发明人:FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G 权利人:FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G; BOEHRINGER INGELHEIM INT 摘要:The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO 2 , preferably SO, and wherein R A , R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.