CAS: 13721-29-4; Sodium Tetrathionate Dihydrate

专利信息

专利号:US-5320943-A
优先权日:1991-03-29
标题 :Methods of detecting T-cell dysfunctions
发明人：FUKUDA MINORU
权利人:JOLLA CANCER RES FOUND
摘要:A method is provided for detecting T-cell dysfunctions. The method includes detecting an alteration in the level of a protein regulating synthesis of the hexasaccharide NeuNAc alpha 2->3Gal beta 1->3(NeuNAc alpha 2->3Gal beta 1->4GlcNAc beta 1->6)GalNAc on leukosialin of T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. The protein regulating synthesis of the hexasaccharide can be core 2 GlcNAc transferase and can be detected by either a change in its amount or activity. Also provided is a method of detecting T-cell dysfunctions which includes detecting an alteration in the level of leukosialin having the hexasaccharide NeuNAc alpha 2->3Gal beta 1->3(NeuNAc alpha 2->3Gal beta 1->4GlcNAc beta 1->6)GlcNAc on T-cells from a subject suspected of having a T-cell dysfunction compared to resting T-cells from a normal individual. Kits for detecting T-cell dysfunction are provided as well.

专利号:US-7635749-B2
优先权日:1999-12-24
标题 :Methods and compositions for prolonging elimination half-times of bioactive compounds
发明人：DENNIS MARK S; LOWMAN HENRY B; DELANO WARREN L
权利人:GENENTECH INC
摘要:Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may comprise any molecule having utility as a therapeutic or diagnostic agent The hybrid molecules of the invention may be prepared using any of a number techniques including production in and purification from recombinant organisms transformed or transfected with an isolated nucleic acid encoding the hybrid molecule, or by chemical synthesis of the hybrid. The hybrid molecules have utility as agents to alter the elimination half-times of active domain molecules. Elimination half-time is altered by generating a hybrid molecule of the present invention wherein the peptide ligand has binding affinity for a plasma protein. In a preferred embodiment, a bioactive molecule having a short elimination half-time is incorporated as or into an active domain of the hybrid molecules of the invention, and the binding affinity of the peptide ligand domain prolongs the elimination half-time of the hybrid as compared to that of the bioactive molecule.

专利号:US-4871670-A
优先权日:1982-08-12
标题 :Molecular cloning and characterization of a gene sequence coding for human relaxin
发明人：HUDSON PETER J; SHINE JOHN; NIALL HUGH D; TREGEAR GEOFFREY W
权利人:FLOREY HOWARD INST
摘要:Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.

专利号:US-6967185-B2
优先权日:2004-01-28
标 题:Synthesis of noble metal, sulphide catalysts in a sulfide ion-free aqueous environment
发明人：ALLEN ROBERT J; GULLA ANDREA F
权利人:DE NORA ELETTRODI SPA
摘要:A noble metal sulfide catalyst obtained by reaction of a precursor of at least one noble metal with a thionic species in an aqueous environment essentially free of sulfide ions useful as an electrocatalyst in the depolarized electrolysis of hydrochloric acid.

专利号:US-5053488-A
优先权日:1982-08-12
标 题 :Molecular cloning and characterization of a gene sequence coding for human relaxin
发明人：HUDSON PETER J; SHINE JOHN; NIALL HUGH D; TREGEAR GEOFFREY W
权利人:FLOREY HOWARD INST
摘要:Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Method for synthesis of the peptides involving recombinant DNA techniques are provided.

专利号:US-7147856-B2
优先权日:1996-08-28
标题 :Stable radioiodine conjugates and methods of their synthesis
发明人：GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable amide bonds are coupled to antibodies. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to antibodies. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to antibodies. In a fourth method, a hydrazide-appended antibody is coupled to a radioiodinated carbohydrate or a thiolated antibody is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated antibody. Radioiodinated residualizing antibody conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.