CAS: 14782-75-3; Aluminum, [ethyl 3-(Oxo-κo)Butanoato-κo′]Bis(2-Propanolato)-, (T-4)-

专利信息

专利号:WO-2025217205-A1
优先权日:2024-04-08
标 题:Synthesis of (-)-trans-δ9-tetrahydrocannabivarin (δ9-thcv) and analogs thereof
发明人：HAGHDOOST MEHDI; ROBERTS MATTHEW; THOMAS BRIAN; DICKINSON LUKE; NIKITIN EDWARD
权利人:NALU BIO INC
摘要:A method is provided for the synthesis of (-)-trans-Δ9-tetrahydrocannabivarin (Δ9-THCV) and analogs thereof such that in the reaction product, the molar ratio of the Δ9 isomer to incidentally formed Δ8 isomers is greater than 4:1. Synthesis is carried out by combining a selected cannabinoid reactant, e.g., cannabidivarin (CBDV) or an analog thereof, with an acid in a solvent for the cannabinoid reactant, wherein the acid comprises (i) a Lewis acid having an acid softness index value in the range of -10 ΔG0 f, M n+ to ‑150 ΔG0 f, M n+, (ii) a Brønsted acid having a pKa in the range of -4.0 to +4.0, or (iii) a combination of (i) and (ii), under reaction conditions comprising a reaction temperature in the range of ‑0 °C to 25 °C and a reaction time in the range of 1 hour to 24 hours. The reaction is thereafter quenched with base and the solvent removed, wherein the crude reaction product so provided may be purified, e.g., chromatographically purified. Also provided is a method for synthesizing Δ9-THCV that further includes synthesis of the cannabinoid reactant. The invention additionally provides novel cannabinoid compositions that may be synthesized using the aforementioned methodology.

专利号:US-5211934-A
优先权日:1990-01-25
标 题:Synthesis of mesoporous aluminosilicate
发明人：KRESGE CHARLES T; LEONOWICZ MICHAEL E; ROTH WIESLAW J; VARTULI JAMES C
权利人:MOBIL OIL CORP
摘要:There is provided a method for synthesizing a new synthetic composition of ultra-large pore crystalline material which can be used as a sorbent or catalyst component for conversion of organic and inorganic compounds. The crystalline material product of this method exhibits unusually large sorption capacity demonstrated by its benzene adsorption capacity of greater than about 15 grams benzene/100 grams at 50 torr and 25° C. This material may have a hexagonal electron diffraction pattern that can be indexed with a d 100 value greater than about 18 Angstom Units and a hexagonal arrangement of uniformly sized pores with a maximum perpendicular cross section of at least about 13 Angstrom Units. The reaction mixture for preparing this material contains a hydrolyzable source of alumina such as aluminum (isopropoxide) 2 acetoacetic ester chelate, and a hydrolyzable source of silica, such as tetraethylorthosilicate.

专利号:US-2023416293-A1
优先权日:2020-11-23
标 题:Synthesis of [18f]-labeled thymidine analogues
发明人：CHEN KAI; CONTI PETER S
权利人:UNIV SOUTHERN CALIFORNIA
摘要:Thymidine analogues, 5-substituted 2′-deoxy-2′-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasively imaging cancer cell proliferation and/or reporter gene expression. We report the radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]FMAU) and other 2′-deoxy-2′-[18F]fluoro-5-substituted-1-β-d-arabinofuranosyluracil analogues using 1,4-dioxane to replace the currently used 1,2-dichloroethane. Compared to 1,2-dichloroethane, 1,4-dioxane is analyzed as a better solvent in terms of radiosynthetic yield and toxicity concern. The use of a less toxic solvent allows for the translation of the improved approach to clinical production. The new radiolabeling method can be applied to an extensive range of uses for 18F-labeling of other nucleoside analogues.

专利号:WO-2024129970-A1
优先权日:2022-12-14
标题:Synthesis of zeolite using hydrous kaolin
发明人：GAO XINGTAO; GILBERT CHRISTOPHER; FU QI; RAI MUKTA; KOBETIC VIJAY
权利人:BASF CORP
摘要:Described herein is a process for preparing a zeolite including mixing an aluminum source, a sodium source and water to form a mixture. After mixing, a silicon source is added and mixed. Then, a zeolite crystal or zeolite seed is added to form a gel mixture, which is then crystallized at a temperature of about 100°C to about 200°C for about 10 to about 108 hours to obtain zeolite crystals.

专利号:WO-2024003151-A1
优先权日:2022-06-28
标 题:Chemical synthesis platform
发明人：CRONIN LEROY
权利人:UNIV GLASGOW COURT
摘要:The invention relates to a method for generating a database for chemical syntheses and a method for performing a chemical synthesis using a database. The method for generating a database comprises generating a series of instruction sets for a series of chemical syntheses from the literature, wherein each instruction set is a machine readable and executable universal language for a chemical synthesiser; assembling the series of instructions sets within a database, and making the instruction sets available for access and autonomous execution by a chemical synthesiser. The method for performing a chemical synthesis comprises accessing an instruction set from a database, providing the instruction set to a chemical synthesiser, and autonomously executing the instruction set on the chemical synthesiser thereby to perform the chemical synthesis. The invention makes use of a standardised and step-focussed syntax to describe the chemical syntheses, and a universal synthesis automation platform.

专利号:WO-2022167387-A1
优先权日:2021-02-03
标 题 :Process for producing carbon monoxide as raw material for isocyanate production with reduced co2 footprint
发明人：BULAN ANDREAS; WEBER RAINER; SCHMIDT TIMM; LETMATHE BERND; ZABALZA GASTON
权利人:COVESTRO DEUTSCHLAND AG
摘要:The invention describes a process for producing carbon monoxide which is intended to be incorporated into a process for producing isocyanates by synthesis (1) of phosgene (1a) from carbon monoxide (9a) and chlorine (12b), reaction (2) of phosgene (1a) with amines (23) to give isocyanates (24) and hydrogen chloride (25), in which process carbon dioxide, methane and water vapour are reacted in a reforming process (6) with supply of heat energy (62) at a temperature of at least 500°C, wherein - the heat energy (62) supplied to the reforming process (6) for the synthesis of carbon monoxide is provided by at least one method selected from (i) the combustion of fuel containing hydrogen produced using renewable energy, (ii) the combustion of fuel containing methane from a biological source, (iii) the conversion of renewably generated electrical energy into heat; and/or - CO2 from a further CO2 source is additionally utilised for providing the CO2 that is added to the synthesis in the aforementioned reforming process (6).