CAS: 174775-48-5; Ethyl 5-Aminobenzofuran-2-Carboxylate

上下游产品

CAS号69604-00-8 5-硝基苯并呋喃-2-羧酸乙酯 | CAS号97-51-8 5-硝基水杨醛 | CAS号163521-12-8 维拉佐酮 | CAS号163521-11-7 5-[4-[4-(5-氰基-1... | CAS号163521-19-5 5-(4-(4-(5-氰基-1... | CAS号89197-62-6 5-氟苯并呋喃-2-羧酸 | CAS号918821-63-3 ethyl 5-methyls... | CAS号929193-49-7 ethyl 5-iodo-1-...

水杨醛置于氢气体系中,用 乙醇 用作溶剂,化学反应 6.0H,以91%的收率获得5-氨基苯并呋喃甲酸乙酯
参考文献:设计,合成,生物学评估取代的苯并呋喃作为结核分枝杆菌的dna Gyraseb抑制剂
标题:设计,合成,生物学评估取代的苯并呋喃作为结核分枝杆菌的dna Gyraseb抑制剂
摘要:结核分枝杆菌(mtb)的dna促旋酶是ii型拓扑异构酶,是开发新型疗法的公认且有效的靶标.通过适应中等通量筛选方法,我们提出了分枝杆菌dna Gyraseb抑制剂的5-(哌嗪-1-基)苯并呋喃-2-羧酸乙酯乙酯系列的发现和优化,选自birla技术和科学研究院(bits)数据库化学约3000个分子的文库.对这些化合物的生物活性进行了测试;化合物22成为对耻垢分枝杆菌的活性最高的有效铅,Ic 50为3.2+/-0.15μmdna Gyraseb酶和0.81+/-0.24μm的mtb超螺旋活性.随后,使用差示扫描荧光法进一步表征最具活性的化合物与dna促旋酶b酶的结合及其热稳定性.
Doi:10.1016/j.Bmc.2014.06.041

专利信息

专利号:US-5977112-A
优先权日:1995-04-20
标 题:Process of making substituted benzofurans
发明人：BATHE ANDREAS; HELFERT BERND; BOTTCHER HENNING; SCHUSTER KURT
权利人:MERCK PATENT GMBH
摘要:Benzofurans of the formula I ##STR1## and their salts in which R 1 , R 2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

专利号:RU-2132848-C1
优先权日:1993-09-30
标题:Derivatives of piperidine and piperazine, method of their synthesis, pharmaceutical compositions containing on said and method of their preparing

专利号:CN-107540646-B
优先权日:2017-08-29
标 题:Synthesis method of vilazodone intermediate

专利号:CN-107674052-B
优先权日:2017-08-29
标题:Synthesis method of vilazodone intermediate 5- (1-piperazinyl) -2-benzofuran-2-carboxylic acid ethyl ester