专利号:US-RE29669-E 优先权日:1973-04-23 标 题:Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides 摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.
专利号:US-4408058-A 优先权日:1982-05-26 标题 :Preparation of ortho-sulfobenzoic acid anhydride by catalyzed thermolysis 发明人:MITCHELL III MARK L; CARR RICHARD P 权利人:SHERWIN WILLIAMS CO 摘要:This invention relates to a process for the synthesis of ortho-sulfobenzoic acid anhydride which comprises heating a 2-sulfohalide benzoate in the presence of a catalytic amount of a Friedel-Crafts catalyst. Especially preferred in the practice of this invention is the reaction of ortho-carbomethoxybenzenesulfonyl chloride in the presence of a zinc or iron halide to produce ortho-sulfobenzoic acid anhydride.
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-3971802-A 优先权日:1974-04-19 标题 :Certain N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)-N-(2-thiazolyl)glycineamides 发明人:LOMBARDINO JOSEPH G 权利人:PFIZER 摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.
专利号:US-3954786-A 优先权日:1974-04-19 标 题 :Isoxazole intermediate compounds 发明人:LOMBARDINO JOSEPH G 权利人:PFIZER 摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150°C., said products being antiinflammatory agents.
专利号:US-3927002-A 优先权日:1973-04-23 标题:N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives 发明人:LOMBARDINO JOSEPH G 权利人:PFIZER 摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N''-alkyl-N''-(2''alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50*-150* C., said products being antiinflammatory agents.