CAS: 27959-26-8; (2-Hydroxycyclohexane-1,1,3,3-Tetrayl)Tetrakis(Methylene) Tetranicotinate

环己酮置于aluminium Trinitrate,Zinc(II) Nitrate,Calcium(II) Nitrate,Sodium Carbonate,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 2.5H,反应生成尼可莫尔
参考文献:一种尼可莫尔的合成方法
标题:一种尼可莫尔的合成方法
摘要:本发明公开了一种尼可莫尔的合成方法,通过将环己醇和浓硫酸混合制得混合液,将混合液与重铬酸钾溶液进行混合反应,使得环己醇上的醇羟基脱氢进而形成酮,将中间体1和多聚甲醛先进行羟醛缩合反应后,在催化剂的作用下进行康农扎罗反应,进而制得中间体2,在制备中间体2的过程中制备的一种催化剂,该催化剂使得中间体2的收率大大提升,烟酸与二氯亚砜进行反应制得烟酰氯盐酸盐,将烟酰氯盐酸盐与中间体2进一步反应制得尼可莫尔,与传统合成方法中使用吡啶作用作溶剂相比,四氢呋喃在使用时不会散发恶臭,且吡啶为毒性较大的物质,操作者在进行操作时,易吸入吡啶进而造成人员伤害,传统的尼可莫尔的收率较低,不适合大规模生产.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications