CAS: 400-93-1; 4'-Fluoro-3'-Nitroacetophenone

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CAS号403-42-9 对氟苯乙酮 | CAS号24430-26-0 1-(4-乙氧基-3-硝基苯基)乙酮 | CAS号2002-82-6 3'-氨基-4'-氟苯乙酮 | CAS号6277-38-9 4'-甲氧基-3'-硝基乙酰苯 | CAS号67500-19-0 2-氟-5-氨基苯乙酮 | CAS号587-02-0 3-乙基苯胺 | CAS号1583-89-7 5-ethyl-2-fluor... | CAS号14347-05-8 4-苄氧基-3-硝基苯乙酮 | CAS号2105-96-6 4-氟-3-硝基苯酚 | CAS号774-86-7 3-Methyl-2-pyri... | CAS号92163-78-5 1-[3-硝基-4-(苯基硫代...

4-氟苯乙酮置于硫酸,硝酸体系中,化学反应 0.5H,反应生成 4'-氟-3'-硝基苯乙酮
参考文献:靶向丙酮酸脱氢酶激酶1的二氯苯乙酮具有提高的选择性和抗增殖活性:合成与构效关系
标题:靶向丙酮酸脱氢酶激酶1的二氯苯乙酮具有提高的选择性和抗增殖活性:合成与构效关系
摘要:二氯苯乙酮是一种丙酮酸脱氢酶激酶1(pdk1)抑制剂,具有次优的激酶选择性.在这里,我们报告了一系列新型二氯苯乙酮的合成和生物学评估.结构-活性关系分析(sars)使我们能够确定3个有效的化合物,即54,55,和64,其抑制pdk1功能,激活丙酮酸脱氢酶复合物,和降低的nci-H1975细胞的增殖.线粒体生物能量学吸附测定法表明,54,55,和64增强的癌细胞中氧化磷酸化,这可能有助于所观测到的抗增殖作用.总的来说,这些结果表明:54,55,和64可以是有前途的化合物为有效的pdk1抑制剂的开发.
DOI:10.1016/j.Bmcl.2018.09.026

专利信息

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:EA-010634-B1
优先权日:2003-04-11
标 题:NEW HETEROCYCLIC COMPOUNDS USED FOR THE TREATMENT OF DISTURBANCES OF ALLERGIC OR INFLAMMATORY NATURE: METHODS OF SYNTHESIS AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS

专利号:CN-101407463-A
优先权日:2008-11-28
标 题 :Catalytic synthesis method of 4-fluoro-3-nitrophenol