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专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-8084638-B2
优先权日:2007-08-03
标题:Sulfanyl derivatives and their use as synthesis intermediates
发明人：LEVEQUE JULIEN; BARBARIN NICOLAS; PALACIO MAGALI
权利人:LEVEQUE JULIEN; BARBARIN NICOLAS; PALACIO MAGALI; UCB PHARMA SA
摘要:The present application relates to sulfanyl derivatives of formula (I) and to their use as synthesis intermediates, especially for the preparation of the pharmaceutically active compound mesna. Formula (I), wherein X is O or N—C(NH)NH 2 ; M+ is hydrogen, sodium, disodium, potassium, dipotassium, ammonium (NH 4 )+, diammonium, quaternary ammonium, calcium or magnesium.

专利号:US-3651041-A
优先权日:1968-03-30
标 题:Acid ion exchangers derived from agarose
发明人：SCHELL HORST D; GHETIE VICTOR F
权利人:INST DE BIOCHIMIE
摘要:THE PRESENT INVENTION DEALS WITH THE SYNTHESIS OF NEW STRONG ACID ION EXCHANGERS DERIVED FROM AGAROSE. THE PROCEDURE FOR OBTAINING THE DERIVATIVES, ACCORDING TO THE INVENTION, CONSISTS IN THE INTRODUCTION OF SULPHOETHYL GROUPS EITHER INTO SIMPLE AGAROSE MOLECULE OR INTO AGAROSE CROSS-LINKED THROUGH GLYCERIC BRIDGES BY MEANS OF EPICHLOROHYDRIN.

专利号:US-2009209032-A1
优先权日:2004-10-01
标 题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

专利号:EP-1848812-A2
优先权日:2004-10-01
标题:Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

专利号:EP-1694637-A4
优先权日:2003-12-17
标题 :PROCESS FOR SYNTHESIS OF DISULFIDENE