CAS: 5579-66-8; 3,6,9,12,15,18,21,24,27-Nonaoxanonacosane-1,29-Diol

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三乙二醇置于4-二甲氨基吡啶,Sodium Periodate,氯化亚砜,Ruthenium(Iii) Chloride Trihydrate,硫酸,水,Sodium Hydride,N,N-二异丙基乙胺体系中,用 四氢呋喃,四氯化碳,二氯甲烷,水,N,N-二甲基甲酰胺,乙腈,Mineral Oil 作为反应溶剂,化学反应 14.5H,反应生成 十甘醇
参考文献:通过低聚乙二醇的高环化高效合成单分散聚乙二醇及其衍生物
标题:通过低聚乙二醇的高环化高效合成单分散聚乙二醇及其衍生物
摘要:已开发出一种基于大环硫酸盐(mcs)的单分散聚乙二醇(m-Peg)及其单官能化衍生物的方法.寡聚乙二醇(oeg)的大环化提供了mcs(最多62个成员的大环),作为一系列单官能化m-Peg的通用前体.通过mcs的反复亲核开环反应而无需进行基团保护和激活,可以轻松制备一系列m-Peg,包括史无前例的64-Mer(2850 Da).合成简单性与这种新策略的多功能性可能为m-Peg的更广泛应用铺平道路.
DOI:10.1002/anie.201410309

专利信息

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:US-5886104-A
优先权日:1993-06-18
标题 :Grafted cross-linked polyolefin substrates for peptide synthesis and assays
发明人：PEDERSEN WALTHER BATSBERG; ALMDAL KRISTOFFER; WINTHER LARS; BERG ROLF HENRIK
权利人:FORSKNIINGSCENTER RISO
摘要:A solid support for the solid-phase synthesis of peptides or proteins in high yield and in high purity, suited both to the synthesis of a single peptide or protein and to the parallel and substantially simultaneous synthesis of a plurality thereof, is based on a cross-linked polyolefin, especially polyethylene, substrate, the cross-linking having been obtained by irradiation with high energy electrons or γ radiation or treatment with organic peroxide such as benzoyl peroxide, to which substrate are grafted polymer chains such as polystyrene chains which are functionalized with a chemical functionality facilitating the formation of an anchoring linkage between the polymer moiety and another chemical species. The solid support is also suited for use in solid-phase biosystems, notably bioassays, such as immunoassays, DNA hybridization assays or PCR amplification. The grafted chains may bear substituents which are such that the polymer-grafted cross-linked polyolefin substrate is swellable by water or aqueous media, in other words, hydrophilic, which makes the solid support particularly well suited for assays of the ELISA type.

专利号:WO-9617589-A1
优先权日:1994-12-08
标 题 :Method of smoothing or removing wrinkles and method of stimulating collagen synthesis
发明人：FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
权利人:KAO CORP; FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
摘要:The present invention relates to methods of stimulating collagen synthesis and of smoothing or removing wrinkles, which comprise administering an effective amount of a benzoic acid derivative of formula (1) or a salt thereof, wherein X is -O- or -N(R4)- (R4 is H or the like), R1 is a C¿4-25?-alkyl or C4-25-alkenyl group, R?2¿ is H, OH, or a C¿1-6?-alkoxyl or C1-6-alkanoyloxy group, and R?3 is -OR5¿ or -N(R?6)R7 (R5? is H, or a C1-25-alkyl or C1-25-alkenyl group), and R?6 and R7¿ are individually H, or a C¿1-3?-alkyl or C1-3-alkenyl group, and use of this compound for agents for stimulating synthesis of collagen, and smoothing or removing wrinkles. This compound (1) stimulates collagen synthesis in human dermal fibroblasts and consequently smooths or removes wrinkles caused by aging and/or photoaging.

专利号:US-9937556-B2
优先权日:2011-11-15
标题 :Templated synthesis of metal nanorods in silica nanotubes
发明人：YIN YADONG; GAO CHUANBO
权利人:UNIV CALIFORNIA
摘要:A method of preparing a metal nanorod. The method includes seeding a metal nanoparticle within the lumen of a nanotube, and growing a metal nanorod from the seeded metal nanoparticle to form a metal nanorod-nanotube composite. In some cases, the nanotube includes metal binding ligands attached to the inner surface. Growing of the metal nanorod includes incubating the seeded nanotube in a solution that includes: a metal source for the metal in the metal nanorod, the metal source including an ion of the metal; a coordinating ligand that forms a stable complex with the metal ion; a reducing agent for reducing the metal ion, and a capping agent that stabilizes atomic monomers of the metal. Compositions derived from the method are also provided.

专利号:US-4466900-A
优先权日:1981-09-22
标 题:Process for the preparation of fluorescent brightener formulations which are stable on storage
发明人：HORLACHER PAUL; PFENNINGER HEINZ
权利人:CIBA GEIGY CORP
摘要:A process is described for the preparation of concentrated liquid formulations, stable on storage, of anionic fluorescent brighteners, which process consists in passing a crude (for example obtained from synthesis) aqueous solution or dispersion of a fluorescent brightener containing sulfo groups, in particular a stilbene fluorescent brightener belonging to the group comprising bistriazinylaminostilbenedisulfonic acids, bis-styrylbiphenyls, bis-styrylbenzenes and bis-triazolylstilbenedisulfonic acids, is passed through a semipermeable membrane which contains ionic groups and has a pore diameter of 1-500 ANGSTROM in order to remove salts and by-products from the synthesis having molecular weights below 500 and in order to remove part of the water. The resulting concentrated preparation can, if desired, be concentrated further and/or treated with formulation assistants and, if desired, further additives.

专利号:US-5585275-A
优先权日:1992-09-02
标 题 :Pilot apparatus for peptide synthesis and screening
发明人：HUDSON DEREK; JOHNSON CHARLES R; GIEBEL LUTZ
权利人:ARRIS PHARM CORP
摘要:Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on or in its surface a plurality of discreet functionalized substrate areas, typically in arrays of 10x10 to 400x400, is provided for chemical synthesis or bonding thereon of desired families of biomolecules (e.g. peptides, DNA, RNA, oligosaccharides). In the case of peptides, such as hexapeptides, the resulting permanently hexapeptide-loaded plate is a reusable Addressable Synthetic Peptide Combinatorial Library (ASPCL), in which 1 to 3 (typically two) of the positions in the sequence are uniquely identified by the address location. The preferred plate embodiment employs an HPMP wink of porous polyolefin removably received in holes in the plate. A unique multi-slot block assembly is used to prepare the ASPCLs. The wink carrier plate is also employed with a vacuum block system to assist in washing, deprotection, and probing. In library applications, for example determining peptides which bind to functional proteins (enzymes, receptors, antibodies), the substrate-bound peptides are assembled with several positions consisting of uniformly distributed equimolar mixtures of residues, and 2 separated or sequential positions uniquely identified by their spatial location on the substrate array, the 'address'. Following identification of the known residues giving the greatest affinity for the arrayed positions in the sequence, optimal binding for the complete peptide sequence is determined by an iterative process replacing formerly mixed positions with known AAs at unique addresses.