CAS: 56-57-5; 4-Nitroquinoline 1-Oxide

上下游产品

CAS号1613-37-2 喹啉-N-氧化物 | CAS号3741-15-9 4-硝基喹啉 | CAS号120309-60-6 | CAS号7664-93-9 硫酸 | CAS号39061-97-7 4-氯-3-硝基喹啉 | CAS号607-31-8 4-甲氧基喹啉 | CAS号4552-43-6 4-氯-2-氰基喹啉 | CAS号36825-36-2 4-氨基-3-溴喹啉 | CAS号486-74-8 4-喹啉羧酸 | CAS号4637-56-3 4-(羟氨基)喹啉 N-氧化物 | CAS号18061-48-8 1-acetoxy-4-ace... | CAS号20146-63-8 2-溴-3-硝基喹啉 | CAS号20151-40-0 2,4-二溴喹啉 | CAS号3741-15-9 4-硝基喹啉

喹啉-N-氧化物置于硫酸,硝酸体系中,化学反应 3.0H,以23%的收率获得产物4-硝基喹啉-N-氧化物
参考文献:在无金属,无活化剂,无碱和无溶剂的条件下,六元n-杂芳族化合物的区域选择性氰化
标题:在无金属,无活化剂,无碱和无溶剂的条件下,六元n-杂芳族化合物的区域选择性氰化
摘要:已开发出使用三甲基甲硅烷基氰化物进行杂芳族n-氧化物的区域选择性氰化,无需任何外部活化剂,金属,碱和溶剂即可获得2-取代的n-杂芳族腈.本协议是一种简单的单锅杂芳族ch氰化方法,可在常规加热中顺利进行,而且在微波辐射下反应时间较短.现在,这种方法可以使用各种各样的喹啉n-氧化物和其他杂芳烃n氧化物的收率很高或很高,也可以按比例放大以获得克量.观测到了该方法的进一步应用,并将其用于抗疟药奎宁的后期氰化以及将2-氰基嗪转化为一系列生物学上重要的分子.基于实验观察,还提出了合理的机理,突出了三甲基甲硅烷基氰化物作为腈源和活化剂的双重作用.
DOI:10.1002/adsc.201901103

专利信息

专利号:US-12215369-B2
优先权日:2019-03-01
标题:Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
发明人：ALEXANDRINO PAULO MOISES RADUAN; GOUVEA IURI ESTRADA; QUEIROZ VERONICA LEITE
权利人:BRASKEM SA
摘要:The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.

专利号:US-2021284618-A1
优先权日:2016-08-12
标 题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention
发明人：BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH
权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV
摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17β-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.

专利号:US-4867914-A
优先权日:1982-02-26
标题:Pregnane derivatives and method of producing the same
发明人：BUNNO MASAYASU; HARADA HIDEMI; TSUJI MASAO; ICHIHARA YOSHIHIRO
权利人:KURARAY CO
摘要:There are provided 12-hydroxy- DELTA 4 or DELTA 1,4-pregnan-3-one-20-carbaldehyde and microbial method of producing the same. The compounds are novel and useful as starting materials for the synthesis of corticoids, typically prednisone, prednisolone and hydrocortisone, which have antiinflammatory activity.

专利号:US-2024207302-A1
优先权日:2021-04-01
标 题 :Antiviral compounds, methods for the manufacturing of compounds, antiviral pharmaceutical composition, use of the compounds and method for the oral treatment of coronavirus infection and related diseases thereof
发明人：CALIXTO JOãO BATISTA; RABI NALLAR JAIME ALBERTO; LOPES E SOUZA THIAGO MORENO
权利人:CALIXTO JOAO BATISTA; RABI NALLAR JAIME ALBERTO; LOPES E SOUZA THIAGO MORENO
摘要:The present invention relates to antiviral compounds selected from cytokinins, their nucleosides and nucleotide analogs, and their prodrugs as inhibitors of viral RNA synthesis, or their salts, solvates, derivatives, or even combinations of aforementioned compounds, for prophylactic treatment, curative (therapeutic) or mitigative coronavirus infection, represented by human and veterinary coronavirus, SARS-COV-2 and MHIV, and for the treatment of individuals potentially exposed to COVID-19. The present invention also comprises the methods for the manufacturing of such compounds, the antiviral pharmaceutical composition containing the compounds of the invention, as well as the use of the compounds, combinations of compounds, and method for the prophylactic, curative (therapeutic) or mitigative treatment of coronavirus infection, represented by coronavirus, in especial SARS-COV-2 and of patients with COVID-19, individual infected with SARS-COV-2 or potentially exposed to this virus. The antiviral activity of the compounds of this invention against SARS-COV-2 was greatly enhanced by inhibiting the 3′-5′-exonuclease. Synergistic results of the compounds according to the present invention were obtained from the combination with repurposed drugs.

专利号:US-2003180391-A1
优先权日:2002-02-20
标 题 :Plant drug for preventing cancer
发明人：ZHAO XINXIAN
摘要:This invention relates to new safe plant drug, which contains Berberine and Baicalin (BB), inhibits carcinogenic and mutagenic action, lowers tyrosine kinase and decreases synthesis of DNA, RNA and protein of cancer cells. n Also, the present invention proved a new radioimmunoassay (RIA) method for precise determination of Berberine and Baicalin. The RIA is an efficient analytical method for large clinical programs including double blind analysis (DBA), and good clinical practice (GCP).

专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.