Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水体系中,化学反应生成 溴乙酸苯酯 参考文献:The Preparation And Alcoholysis Of Phenyl Iminoester Hydrochlorides 标题:The Preparation And Alcoholysis Of Phenyl Iminoester Hydrochlorides 摘要: DOI:10.1021/ja01220A507
专利号:US-9988364-B1 优先权日:2017-03-21 标题 :Process for synthesis of Eliglustat and intermediate compounds thereof 发明人:LIU YU; YU GUANNENG; ZHENG ZHIGUO 权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD 摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.
专利号:US-9546161-B2 优先权日:2001-07-16 标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors 发明人:HIRTH BRADFORD H; SIEGEL CRAIG 权利人:GENZYME CORP 摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
专利号:US-4965397-A 优先权日:1989-01-23 标题:Novel dibasic acid salts and their synthesis 发明人:SCHACHT ETIENNE; CROMMEN JAN 权利人:ETHYL CORP 摘要:The protecting group, Z, of protected alpha-amino acid esters of the formula n n Z--NH--CH(R.sub.2)COOCH(R)COOR.sub.1 n n is removed in the presence of a dibasic acid such as oxalic acid. This results in the formation of a new type of salt of an amino acid ester which may be represented by the formula ##STR1## In the above Q is a divalent hydrocarbyl residue of a dibasic acid, R is a hydrogen atom or hydrocarbyl group, R 1 is a hydrocarbyl group, R 2 is a hydrogen atom or hydrocarbyl group, and p is zero or one, preferably zero. When p is zero, the salts are oxalate salts. When p is one, the salts are salts of other dibasic acids. The salts (II) are useful as reactants in the synthesis of amino-acid substituted phosphazene polymers.
专利号:WO-8911473-A1 优先权日:1988-05-27 标 题:Process for the synthesis of o-substituted oxime compounds 发明人:CHEMPOLIL THOMAS MATHEW 权利人:ALLIED SIGNAL INC 摘要:A novel process for the production of O-substituted oximes is disclosed. The process involves reacting an oxime with an alkali-metal hydroxide optionally in a solvent which forms an azeotrope with water to form a mixture of the alkali metal salt of the oxime and water, removing all or a portion of the water by distilling the mixture azeotropically and reacting the distilled mixture with an alpha halo carboxylic acid.
专利号:US-4769451-A 优先权日:1985-08-15 标 题:Synthesis of carbapenems using n-substituted azetidinones 发明人:DEXTRAZE PIERRE 权利人:BRISTOL MYERS CO 摘要:A novel process is disclosed for converting known 3,4-disubstituted azetidinones to carbapenems. The process proceeds through novel N-substituted intermediates and then cyclizes to the 4-position of the azetidinone to form the carbapenem.
专利号:US-4973687-A 优先权日:1985-08-15 标 题:Synthesis of carbapenems using N-substituted azetidinones 发明人:DEXTRAZE PIERRE 权利人:BRISTOL MYERS CO 摘要:This invention provides novel azetidinone intermediates having the formulas: ##STR1## wherein R 1 is hydrogen, or a conventional hydroxy-protecting groups; R 2 , R 4 , and R 5 are independently selected from the group consisting of hydrogen; substituted and unsubstituted: alkyl, alkenyl, and alkynyl having from 1-10 carbon atoms; cycloalkyl, cycloalkylalkyl, and alkylcycloalkyl having 3-6 carbon atoms in the cycloalkyl ring and 1-6 carbon atoms in the alkyl moieties; spirocycloalkyl having 3-6 carbon atoms; phenyl; aralkyl, aralkenyl, and aralkynyl wherein the aryl moiety is phenyl and the aliphatic portion has 1-6 carbon atoms; or various heterocyclic moieties; and R 6 is methanesulfonyl or p-toluenesulfonyl; which are useful in the preparation of carbapenem antibiotics.
[参考文献]: Robert M Williams, Et Al. New Tricks In Amino Acid Synthesis: Applications To Complex Natural Products. Acs Symp Ser Am Chem Soc. 2009 Jun 14:1009:420-442.
合成参考文献
摘要:Landais, Y., Science of Synthesis Knowledge Updates, (2013) 3, 48. 摘要:Heydt, H., Science of Synthesis Knowledge Updates, (2014) 3, 414. 摘要:Zeitler, K., Science of Synthesis, (2019) , 321.