CAS: 74-69-1; 2-Methyl-4-Pyrimidinamine

相似化合物

591-54-8 856974-20-4 88613-86-9

上下游产品

4-chloro-2-methylpyrimidine 2-methylpyrimidine ammonia 4-nitro-benzenesulfonic acid-(2-methyl-pyrimidin-4-ylamide) sulphamerazine 3-cyclopentyl-2-(4-methanesulfonyl-3-nitro-phenyl)-N-(2-methyl-pyrimidin-4-yl)-propionamide 2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(2-methyl-pyrimidin-4-yl)-propionamide

2-甲基嘧啶置于potassium Permanganate,Sodium Amide体系中,化学反应生成 2-甲基-4-氨基嘧啶
参考文献:Buurman,Dick J.; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1987,Vol. 24,P. 1377-1380
标题:Buurman,Dick J.; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1987,Vol. 24,P. 1377-1380

专利信息

专利号:US-3689498-A
优先权日:1970-07-20
标题 :Halide and sulfate salts of 5-amino-isoxazolylmethylene dialkylamine
发明人：LEIMGRUBER WILLY; WEIGELE MANFRED
权利人:HOFFMANN LA ROCHE
摘要:Halide and sulfate salts of 5-amino-4-isoxazolylmethylene dialkylamine and a process for the preparation of these salts. These salts are intermediates for 4-amino-2-methylpyrimidine utilized in the synthesis of thiamine.

专利号:US-3792076-A
优先权日:1972-02-04
标 题:Process for the preparation of 4-amino-2-methylpyridine 5-carboxamide
发明人：LEIMGRUBER W; WEIGELE M
权利人:HOFFMANN LA ROCHE
摘要:THIS INVENTION IS DIRECTED TO A PROCESS FOR THE PREPARATION OF 4-AMINO-2-METHYLPYRIMIDINE 5-CARBOXAMINE FROM 2-CYANO-3-DI(LOWER ALKYL)AMINO ACROLEIN. THE 4-AMINO2-METHYLPYRIMIDINE 5-CARBOXAMIDE IS A KNOWN COMPOUND WHICH IS A VALUABLE INTERMEDIATE IN THE SYNTHESIS OF THIAMINE.

专利号:US-9828386-B2
优先权日:2013-11-15
标题:Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
发明人：TANG YAJIE; LI JIANLONG; ZHAO WEI; LI HONGMEI
权利人:UNIV HUBEI TECHNOLOGY
摘要:The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a rigid aromatic heterocyclic compound, as well as a further sulfonamidated product of 3-amino-5-mercapto-1,2,4-triazole, 2-amino-5-mercapto-1,3,4-thiadiazole, 4-methylbenzenesulfonyl chloride, or 4-methoxybenzenesulfonyl chloride as a substituent group, into position 4 of the C-ring of podophyllotoxin or 4′-demethylepipodophyllotoxin to obtain the podophyllotoxin derivative shown in formula (V), said derivative having significantly increased antitumor activity and reduced toxic side effects. Experiments on in vitro tumor cell inhibition indicate that the antitumor activity of the compound of formula (V) of the present invention is significantly higher than the antitumor activity of podophyllotoxin or 4′-demethylepipodophyllotoxin.

专利号:US-8476313-B2
优先权日:2004-08-26
标 题:Heteroaryl-containing isoflavones as aromatase inhibitors
发明人：BRUEGGEMEIER ROBERT W; KIM YOUNG-WOO; HACKETT JOHN C
权利人:BRUEGGEMEIER ROBERT W; KIM YOUNG-WOO; HACKETT JOHN C; UNIV OHIO STATE RES FOUND
摘要:Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: n nwherein X is selected from O, N, S, SO, SO 2 , and S(CH 2 ) n , wherein n=1-10; R 1 and R 2 may be the same or different and are selected from H, OH, OCH 3 , OCH 2 CH 3 , OCH 2 C 6 H 5 , NH 2 , NHCH 3 , N(CH 3 ) 2 , CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , NO 2 , F, Cl, Br, CF 3 , SH, SCH 3 , SCH 2 CH 3 , OCOCH 3 , OCOC(CH 3 ) 3 , OCOCH 2 COOH, and CN; and R 3 is a nitrogen-containing heterocyclic ring. Also provided are method for treating or preventing cancer in a subject by administering a therapeutically effective amount of a heteroaryl-containing isoflavone, or a pharmaceutically acceptable salt or prodrug thereof, to a subject in need of treatment. Also provided is a method for the synthesis of 2-substituted isoflavones by first reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone; second deprotecting the 2-(alkylthio)isoflavone; and third applying selective debenzylation to form the final compound.

专利号:WO-2025151642-A1
优先权日:2024-01-09
标题 :Modified elongation factor p and methods of use thereof
发明人：HECHT SIDNEY; DEDKOVA LARISA; POTUGANTI GAL REDDY; DASKALOVA SASHA
权利人:UNIV ARIZONA STATE
摘要:Provided herein are modified elongation factor P (EF-P) enzymes capable of incorporating noncanonical amino acids during protein synthesis at efficiencies that are different than those of native EF-P. Also provided are methods for preparing and using modified EF-P enzymes.

专利号:EP-2102172-B1
优先权日:2007-01-19
标 题:Synthesis of 4-amino-pyrimidines