CAS: 104206-65-7; 2-(2-Nitro-4-(Trifluoromethyl)Benzoyl)Cyclohexane-1,3-Dione

上下游产品

2-硝基-4-三氟甲基苯甲酸 2-Nitro-4-Trifluoromethylbenzoic Acid 320-94-5
2-硝基-4-(三氟甲基)苯甲酰氯 2-Nitro-4-Trifluoromethyl-Benzoyl Chloride 81108-81-8

2-硝基-4-三氟甲基苯甲酸置于草酰氯,三甲基氰硅烷,三乙胺,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 2.33H,反应生成尼替西农
参考文献: Pharmaceutical Composition[fr] Composition Pharmaceutique
标题: Pharmaceutical Composition[fr] Composition Pharmaceutique
摘要:本发明涉及口服药物组成物,包括尼替酮或其药学上可接受的盐,它们在酪氨酸血症的治疗中的使用,例如遗传性酪氨酸血症1型(ht-1)或黑酸尿症.该组成物具有改善的稳定性特征.本发明还涉及生产尼替酮的过程.

专利信息

专利号:US-12234495-B2
优先权日:2021-04-06
标 题:Synthesis of beta-hydroxyisovalerate and methods of use
发明人：VEMURI GOUTHAM; LINDSAY CHRISTOPHER; ROBERG-PEREZ KEVIN; SNOW CHRISTOPHER D; CAMERON ELIZABETH A
权利人:SASYA INC
摘要:The biological production of beta-hydroxyisovalerate (βHIV) using at least one non-natural enzyme. The non-natural enzyme for the biologically-derived βHIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural enzyme having one or more modifications of substrate-specificity positions. The non-natural enzyme can be expressed in a microorganism, such as a yeast or bacteria, wherein the microorganism comprises an active βHIV metabolic pathway for the production of βHIV. Alternatively, the non-natural enzyme can be a βHIV synthase used to produce βHIV in a cell-free environment. The biological derivation of βHIV eliminates toxic by-products and impurities that result from the chemical production of βHIV, such that βHIV produced by a non-natural enzyme prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.

专利号:US-9783485-B1
优先权日:2016-11-30
标题:Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
发明人：ATTOLINO EMANUELE
权利人:DIPHARMA S A
摘要:The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.

专利号:US-2025002949-A1
优先权日:2021-04-06
标题:Synthesis of beta-hydroxyisovalerate and methods of use

专利号:US-11920177-B2
优先权日:2021-04-06
标题 :Synthesis of beta-hydroxyisovalerate and methods of use

专利号:US-2022315954-A1
优先权日:2021-04-06
标 题 :Synthesis of beta-hydroxyisovalerate and methods of use

专利号:US-2022325304-A1
优先权日:2021-04-06
标 题:Synthesis of beta-hydroxyisovalerate and methods of use