CAS: 29682-41-5; 1,4-Dichloro-2-Iodobenzene

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CAS号135145-90-3 2,5-二氯苯硼酸 | CAS号106-46-7 1,4-二氯苯 | CAS号95-82-9 2,5-二氯苯胺 | CAS号63069-48-7 2-碘-4-氯苯胺 | CAS号89-61-2 2,5-二氯硝基苯 | CAS号15470-55-0 2,5-二氯苯胺 | CAS号861081-48-3 3,6-dichloro-2-... | CAS号5326-39-6 4-碘-3-硝基甲苯 | CAS号13194-69-9 2-碘-5-甲基苯胺 | CAS号41464-42-0 2,3',5,5'四氯联苯 | CAS号38379-99-6 2,2'3,5',6-五氯联苯 | CAS号52663-63-5 2,2',3,5,5',6-六氯联苯 | CAS号41464-41-9 2,2',5,6'-四氯联苯 | CAS号32598-11-1 2,3,4,5-四氯联苯醚 | CAS号35693-99-3 异辛烷/甲苯中PCB52溶液标准物质 | CAS号34883-39-1 2,5-二氯联苯 | CAS号38444-81-4 2,3',5-三氯联苯 | CAS号20595-47-5 2,5-二氯肉桂酸 | CAS号106-46-7 1,4-二氯苯

1,4-二氯苯置于2,2,6,6-Tetramethylpiperidinyl-Lithium,碘体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,反应生成1,4-二氯-2-碘苯
参考文献:间歇式反应器中卤代芳基锂的去质子化生成和捕集
标题:间歇式反应器中卤代芳基锂的去质子化生成和捕集
摘要:公开了一种通过去质子化锂化对卤代芳烃进行区域选择性官能化的方法.生成的卤代芳基锂被捕获在带有氯化锌二胺复合物的间歇式反应器中,以提供没有芳炔形成的有机锌物质,其与亲电子试剂反应以 38-98% 的收率提供相应的产物.将该方法应用于克级卡巴佐霉素a的五步全合成,总收率为33%.
Doi:10.1021/acs.Orglett.3C00800

专利信息

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-4341706-A
优先权日:1980-10-10
标题 :Process for the preparation of carbapenem antibiotics
发明人：CHRISTENSEN BURTON G; SHIH DAVID H
权利人:MERCK & CO INC
摘要:Disclosed is a process for the synthesis of carbapenem antibiotics I and their pharmaceutically acceptable salts and esters from 1: wherein: R7, R6, R1, R2 and R8 are selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, spirocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, aralkyl, aralkenyl, aralkynyl, heteroalkyl, heteroaralkyl, heterocyclyl and heterocyclyalkyl.

专利号:US-4460507-A
优先权日:1980-10-10
标题:Process for the preparation of thienamycin
发明人：SHIH DAVID H
权利人:MERCK & CO INC
摘要:Disclosed is a process for the total synthesis of thienamycin from descysteaminylthienamycin 1 ##STR1## via thienamycin sulfoxide 4: ##STR2## R 3 , R°, R' are blocking groups.

专利号:US-4341705-A
优先权日:1980-10-10
标 题 :Thienamycin derivatives
发明人：SHIH DAVID H
权利人:MERCK & CO INC
摘要:Disclosed is a process for the total synthesis of thienamycin from descysteaminylthinamycin 1 ##STR1## via thienamycin sulfoxide 4: ##STR2## R 3 , R°, R' are blocking groups.

专利号:EP-3210987-A1
优先权日:2007-08-06
标 题:Process for the synthesis of proteasome inhibitors