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6-甲基吡啶-3-甲酸乙酯置于ammonium Hydroxide,三氯氧磷体系中,化学反应生成 5-氰-2-甲基吡啶
参考文献:枯萎病和抗生素.第十五次沟通.岩藻酸的组成与合成.5-乙基和5-正己基吡啶-2-羧酸的合成
标题:枯萎病和抗生素.第十五次沟通.岩藻酸的组成与合成.5-乙基和5-正己基吡啶-2-羧酸的合成
摘要:从番茄枯萎病菌中分离富马酸.,镰刀菌感染.和gibberella Fujikuroi (saw.)woll.描述.该化合物与合成生产的5-正丁基吡啶-2-羧酸相同.为了确定它们的萎wil作用,还合成了5-正己基和5-乙基吡啶-羧酸.
DOI:10.1002/hlca.19540370504

专利信息

专利号:US-8138188-B2
优先权日:2006-02-23
标题 :Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM; PFIZER
摘要:The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) n nwherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

专利号:US-5322852-A
优先权日:1992-02-17
标 题:Aminooxy piperidines as ornithine decarboxylase inhibitors
发明人：FREI JOERG; STANEK JAROSLAV
权利人:CIBA GEIGY CORP
摘要:The invention relates to compounds of formula I (I) wherein either R1 is a radical of formula Ia, -(CH2)n-O-NH2(Ia) in which n is 0 or 1, is hydrogen and R2 is a radical of formula Ib, -(CH2)p-O-NH2(Ib) in which p is 1 or 2, and wherein R is C1-C2alkyl which is attached to one carbon atom of the central piperidine ring system, but not to the same carbon atom as R1 of formula Ia or as R2 of formula Ib; and m is 1 or 2, and salts thereof. The invention further relates to the preparation of these compounds, to intermediates obtained during their synthesis, to pharmaceutical compositions which contain them, and to the use of said compounds for the therapeutic treatment of the human or animal body and for the preparation of pharmaceutical compositions. The compounds of formula I are inhibitors of ornithin decarboxylase.

专利号:WO-2013153539-A1
优先权日:2012-04-13
标 题:Tricyclic compounds as tec kinase inhibitors
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; KHAIRATKAR-JOSHI NEELIMA; SHAH DAISY MANISH
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention is directed to tricyclic compounds of formula (I) as Tec kinase inhibitors, in particular ITK (interleukin-2 inducible tyrosine kinase) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by ITK.

专利号:WO-2014024119-A1
优先权日:2012-08-06
标 题:Heterocyclic amides as itk inhibitors
发明人：KUMAR SUKEERTHI; THOMAS ABRAHAM; CHIKHALE RAJENDRA PRAKASH; WAGHMARE NAYAN TATERAO; KADLAG NANASAHEB; KHAIRATKAR-JOSHI NEELIMA; SHAH DAISY MANISH
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention is directed to heterocyclic amide compounds of formula (I) as Tec kinase inhibitors, in particular ITK (interleukin-2 inducible tyrosine kinase) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by ITK.