CAS: 3460-18-2; 1,4-Dibromo-2-Nitrobenzene

上下游产品

CAS号106-37-6 对二溴苯 | CAS号98-95-3 硝基苯 | CAS号99277-71-1 2-硝基-4-溴苯甲酸 | CAS号14938-99-9 N-[2-Nitro-phen... | CAS号577-19-5 邻溴硝基苯 | CAS号106-40-1 对溴苯胺 | CAS号7697-37-2 硝酸 | CAS号105003-96-1 2-(4-bromo-2-ni... | CAS号33696-00-3 4-溴-2-硝基苯甲醚 | CAS号91062-48-5 5-溴-2-吗啉-4-苯胺 | CAS号199328-35-3 4-溴-2-硝基苯乙酸乙酯 | CAS号22230-49-5 1,2,4,5-tetrabr... | CAS号199328-34-2 diethyl 2-(4-br... | CAS号3652-90-2 2-溴咔唑 | CAS号88590-00-5 2-苯基-9H-咔唑 | CAS号3638-73-1 2,5-二溴苯胺 | CAS号25462-68-4 2,5-Dibromo-4-n...

4-溴-2-硝基苯甲酸置于氧气,Silver Carbonate,Potassium Hydroxide,Copper(Ll) Bromide体系中,用 二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,以60%的收率获得2,5-二溴硝基苯
参考文献:银催化的羧酸脱羧卤化
标题:银催化的羧酸脱羧卤化
摘要:报道了由碳酸银催化的羧酸的脱羧卤化.在130-140oc下,邻硝基硝基苯甲酸与氯化铜(II)或溴化物在dmf / Dmso中反应,以中等至非常好的收率生成相应的芳基卤化物.
Doi:10.1016/j.Tetlet.2010.10.054

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2012172350-A1
优先权日:2009-09-11
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:US-9096623-B1
优先权日:2014-05-08
标 题 :Method for preparing radiotracer precursor SnADAM
发明人：LEE CHING-YUN; CHANG YU; HSU CHENG-FANG; DENG YUEH-FENG
权利人:ATOMIC ENERGY COUNCIL—INST OF NUCLEAR ENERGY RES
摘要:A method for preparing a radiotracer precursor SnADAM is revealed. The method overcomes shortcomings of conventional synthesis methods including lower yield rate and time-consuming. Moreover, Pd/C catalyst and hydrogen gas are used to catalyze reduction reaction for avoiding the generation of a large amount of intermediate products with similar structures. Thus there is no need to perform isolation and purification processes. The yield rate of the intermediate products is also increased so that its impact on the low yield rate of the final product SnADAM is minimized. A part of the reaction is significantly accelerated by using tris(dibenzylideneacetone)-dipalladium(0) (Pd 2 (dba) 3 ) as a catalyst. Thus the production time of SnADAM is shortened.

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles