CAS: 51077-01-1; Tos-Pro-Oh

相似化合物

101555-62-8 1148-11-4 147-85-3

上下游产品

CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号147-85-3 脯氨酸 | CAS号147-85-3 脯氨酸

N-Tosyl-L-Prolyl Chloride置于sodium Hydroxide,三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 24.5H,反应生成 1-(甲苯-4-磺酰基)-吡咯烷-2-羧酸
参考文献:Preparation Of Both Enantiomers Of 1-Allyl-1,2,3,4-Tetrahydro-β-Carboline Using Allyltin Reagents And A Chiral Auxiliary Derived From L-Proline
标题:Preparation Of Both Enantiomers Of 1-Allyl-1,2,3,4-Tetrahydro-β-Carboline Using Allyltin Reagents And A Chiral Auxiliary Derived From L-Proline
摘要:Beta-Carboline,Which Had An Acyl Group Derived From L-Proline At The 9-Position,Reacted With Allyltributyltin And 2,2,2-Trichloroethyl Chloroformate,To Afford An 1-Allyl-1,2-Dihydro-Beta-Carboline Derivative In A Diastereo Selective Manner. The Chiral Acyl Group At N-9 Was Readily Eliminated By Aqueous Alkali To Give A Corresponding Carboxylic Acid. The Formed 1-Allyl-1,2-Dihydro-Beta-Carboline Was Transformed Via Two Reduction Steps To 1-Alkyl-1,2,3,4-Tetrahydro-Beta-Carboline In High Ee. When The Allylation Was Carried Out Using Tetraallyltin Instead Of Allyltributyltin,The Stereoselectivity Was Reversed,And The Antipode Of The Allyl Adduct Was Obtained In High Yield And Ee In The Presence Of Tin(Iv) Tetraiodide. Thus,It Was Found That Both Enantiomers Of 1-Allyl-Beta-Carboline Were Obtained In Good Enantioselectivities By The Use Of The Same Chiral Auxiliary. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4020(01)00684-6

专利信息

专利号:US-10030003-B2
优先权日:2014-09-10
标 题:Synthesis of isoflavanes and intermediates thereof
发明人：BELIAEV NIKOLAI; SHAFRAN YURI
权利人:SYSTEM BIOLOGIE AG
摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

专利号:US-2006148046-A1
优先权日:2004-12-31
标题 :Enzymatic process for the preparation of an intermediate compound and use thereof for the synthesis of tamsulosin hydrochloride

专利号:CA-2960437-A1
优先权日:2014-09-10
标 题 :Synthesis of isoflavanes and intermediates thereof

专利号:US-2017283389-A1
优先权日:2014-09-10
标题 :Synthesis of Isoflavanes and Intermediates Thereof

专利号:WO-2024216095-A1
优先权日:2023-04-13
标 题 :Synthesis of mavorixafor and intermediates thereof
发明人：SEKIRNIK ANGELINA ROBERTA; TAVERAS ART; HANSELMANN ROGER; GAO FENG; ZHAO ZHIGANG
权利人:X4 PHARMACEUTICALS INC
摘要:The present invention relates to methods for synthesizing the C-X-C receptor type 4 (CXCR4) inhibitor mavorixafor and to intermediates thereto.

专利号:WO-2006070285-A2
优先权日:2004-12-31
标题 :Enzymatic preparation of an intermediate compound for the synthesis of tamsulosin