CAS: 596-51-0; 3-(2-Cyclopentyl-2-Hydroxy-2-Phenylacetoxy)-1,1-Dimethylpyrrolidin-1-Ium Bromide

上下游产品

methyl bromide 3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine 1-methyl-3-pyrrolidinol 2-cyclopentyl-2-hydroxy-2-phenylacetic acid3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium iodide [(cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium chloride [(cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium chloride 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium benzoate

Cyclopentylglyoxylsaeure置于4-二甲氨基吡啶,Magnesium,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,二氯甲烷,氯仿,乙腈 作为反应溶剂,化学反应 73.0H,反应生成 甘罗溴铵
参考文献: Process For Synthesis Of Glycopyrronium Bromide[fr] Procédé De Synthèse De Bromure De Glycopyrronium
标题: Process For Synthesis Of Glycopyrronium Bromide[fr] Procédé De Synthèse De Bromure De Glycopyrronium
摘要:本文提供了一种制备溴化甘可维铵的方法,包括将n-甲基吡咯烷-3-醇与式i或式ii化合物反应,随后进行额外的步骤.

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2022389172-A1
优先权日:2021-06-04
标 题:Synthesis of oligosaccharides as prebiotics from simple sugars and polysaccharides in concentrated acids
发明人：PAN XUEJUN; ZENG MEIJUN; LI NING
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are methods for preparing a product including predominantly prebiotic oligosaccharides by non-enzymatic methods of glycosylation of monosaccharides, disaccharides, and/or polysaccharides. The methods may include mixing one or more types of monosaccharides, disaccharides, and/or polysaccharides with an effective amount of a dehydrating acid at a temperature sufficient to form a product including predominantly prebiotic oligosaccharides.

专利号:US-3691198-A
优先权日:1970-12-21
标题 :Synthesis of 1-substituted-3-halopyrrolidines
发明人：BROWN BERNARD BEAN; RUOPP DONALD CARL
权利人:CPC INTERNATIONAL INC
摘要:A method of preparing 1-substituted-3-halopyrrolidines, particularly a method of preparing said pyrrolidines by reacting a 1-substituted- Delta 3-pyrroline with a concentrated hydrogen halide aqueous solution at a temperature greater than 100*C. In a preferred embodiment, a supersaturated hydrobromic acid solution is utilized, i.e., one containing about 60 percent hydrogen bromide. The 1-substituted- Delta 3-pyrroline reactant is preferably made by reaction of a cis-1,4-dihalobutene-2 with a primary amine whereupon cyclization takes place. Said 1substituted-3-halopyrrolidines are intermediates useful in making anti-cholinergics and like materials.

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2018154597-A1
优先权日:2017-02-22
标题:Process for synthesis of glycopyrronium bromide
发明人：REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP
权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH
摘要:Provided herein are processes for preparation of glycopyrronium bromide comprising reaction of N-methylpyrrolidin-3-ol with compounds of Formula I or Formula II followed by additional steps.

专利号:US-6030613-A
优先权日:1995-01-17
标题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.