CAS: 736992-21-5; L-Phenylalaninamide, D-Arginyl-2,6-Dimethyl-L-Tyrosyl-L-Lysyl-

上下游产品

Nα-Benzyloxycarbonyl-Lysyl(Nε-T-Butyloxycarbonyl)Phenylalaninamide 17337-68-7

2',6'-二甲基-L-酪氨酸置于palladium 10% On Activated Carbon,氢气,碳酸氢钠,1-羟基苯并三唑,1-丙基磷酸酐,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺,乙酰氯,Lithium Hydroxide体系中,用 1,4-二氧六环,甲醇,二氯甲烷,水,N,N-二甲基甲酰胺,异丙醇 作为反应溶剂,40.0 °C,101.33 Kpa 条件下,反应 58.42H,反应生成 D-精氨酰-2,6-二甲基-L-酪氨酰-L-赖氨酰-L-苯丙氨酰胺
参考文献: Processes For Preparing Pharmaceutically Relevant Peptides[fr] Méthodes De Préparation De Peptides Pertinents Sur Le Plan Pharmaceutique
标题: Processes For Preparing Pharmaceutically Relevant Peptides[fr] Méthodes De Préparation De Peptides Pertinents Sur Le Plan Pharmaceutique
摘要:目前的技术提供了产生肽,肽的药用可接受盐和中间体的方法.在某些实施例中,该肽为d-Arg-2´6´-Dmt-Lys-Phe-Nh2.

专利信息

专利号:US-12018094-B2
优先权日:2018-04-02
标 题 :Crystalline dipeptides useful in the synthesis of elamipretide
发明人：DUNCAN SCOTT M; REDMON MARTIN P
权利人:STEALTH BIOTHERAPEUTICS INC
摘要:Disclosed are crystalline forms of L-Lys(Boc)-Phe-NH2 and Boc-D-Arg-DMT. The crystalline forms may be used in the synthesis of elamipretide.

专利号:US-10961273-B2
优先权日:2016-08-16
标 题 :N-carboxyanhydride-based-scale synthesis of elamipretide
发明人：DUNCAN SCOTT M; OUDENES JAN; ANDERSEN MARC W
权利人:STEALTH BIOTHERAPEUTICS CORP
摘要:Disclosed are methods of making elamipretide (MTP-131), a peptide compound with therapeutic potential for treating various mitochondrial myopathies. The synthesis of the peptide can be achieved via the use of N-carboxyanhydride-modified amino acid residues, which increases the efficiency of the synthetic process and the purity of the peptide product generated.

专利号:US-10112976-B2
优先权日:2014-06-30
标 题:Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
发明人：ZHAO XINJUN; ZHENG MINYU; YU XIAOZHONG; GAO HANRONG; CORNILLE FABRICE
权利人:FLAMMA SPA
摘要:The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

专利号:PT-3774844-T
优先权日:2018-04-02
标 题:Crystalline dipeptides useful in the synthesis of elamipretide

专利号:US-10125164-B2
优先权日:2014-06-25
标题:Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
发明人：ZHAO XINJUN; ZHENG MINYU; YU XIAOZHONG; GAO HANRONG; CORNILLE FABRICE
权利人:FLAMMA SPA
摘要:The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

专利号:EP-4219523-A3
优先权日:2018-04-02
标题:Crystalline dipeptides useful in the synthesis of elamipretide