CAS: 91374-20-8; 4-(2-(Dipropylamino)Ethyl)Indolin-2-One Hydrochloride

上下游产品

CAS号91374-25-3 2-[2-(二丙基氨基)乙基]... | CAS号142-84-7 二正丙胺 | CAS号120427-96-5 4-(2-溴乙基)氧化吲哚 | CAS号120427-95-4 4-(2-溴乙基)-3-氯-1... | CAS号91374-21-9 罗匹尼罗 | CAS号863436-07-1 2-{2-[2-(diprop... | CAS号139122-20-6 4-(2'-羟乙基)氧化吲哚对甲苯磺酸酯 | CAS号920986-68-1 2-(2-甲基-3-硝基苯基)... | CAS号139122-17-1 4-[2-(苯甲酰氧基)乙基]... | CAS号139122-18-2 4-[2-(苯甲酰基氧基)乙基... | CAS号91374-21-9 罗匹尼罗

累匹利洛置于盐酸体系中,用 异丙醇,甲苯 作为反应溶剂,化学反应 1.0H,反应生成 4-(2-二正丙基胺乙基)-1,3-二氯-2H-吲哚-2-酮
参考文献: Substantially Pure 4-[2-(Di-N-Propylamino)Ethyl]-2(3H)-Indolone Hydrochloride[fr] Hydrochlorure De 4-[2-(Di-N-Propylamino)Ethyl]-2(3H)-Indolone Sensiblement Pur
标题: Substantially Pure 4-[2-(Di-N-Propylamino)Ethyl]-2(3H)-Indolone Hydrochloride[fr] Hydrochlorure De 4-[2-(Di-N-Propylamino)Ethyl]-2(3H)-Indolone Sensiblement Pur
摘要:具有高效液相色谱纯度等于或大于99.5%的极纯4-[2-(二异丙基氨基)乙基]-2(3H)-吲哚酮盐酸盐及其制备方法.

专利信息

专利号:US-2008125354-A1
优先权日:2005-11-21
标题 :Selective inhibition of matrix metalloproteinases
发明人：FIELDS GREGG B; HAMMER ROBERT
权利人:UNIV FLORIDA ATLANTIC; UNIV LOUISIANA STATE
摘要:Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人：TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:US-8883831-B2
优先权日:2008-11-05
标题 :Compositions and methods for minimizing or reversing agonist-induced desensitization
发明人：BEAR DAVID M; KESSLER ROBERT M
权利人:PHARMORX THERAPEUTICS INC
摘要:Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated administration of the drug to a patient. The method includes administering to the patient a dopamine receptor agonist or partial agonist or a drug that increases the extracellular level of dopamine by enhancing release of dopamine, decreasing the removal of dopamine from the extracellular space, enhancing the synthesis of dopamine within the brain, or decreasing metabolic degradation of dopamine; and also administering to the patient an opioid receptor antagonist in an ultra-low dose amount, wherein the ultra-low dose amount is effective to prevent or reverse loss of therapeutic effects associated with the repeated administration of the drug to the patient. The methods are useful for various treatments, including treating Parkinson's Disease, Restless Leg Syndrome, depression, schizophrenia, psychostimulant drug abuse, or attention deficit disorder.

专利号:US-10458995-B2
优先权日:2016-03-25
标 题 :Combinatorial synthesis and biomarker development
发明人：MOOLA MURALIDHAR REDDY
权利人:MOOLA MURALIDHAR REDDY
摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:IL-206586-A
优先权日:2001-03-19
标 题 :A method for the formation of small molecules by patterned synthesis of nucleic acid