专利号:US-9382288-B2 优先权日:2010-10-06 标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action 发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO 权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG 摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
专利号:WO-9925385-A1 优先权日:1997-11-17 标 题:A method of increasing nucleic acid synthesis with ultrasound 发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID 权利人:IMARX PHARMACEUTICAL CORP 摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
专利号:US-9562037-B2 优先权日:2014-02-26 标题:Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents 发明人:CHOW LARRY MING-CHEUNG; CHAN WILLIAM TAK HANG; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU 权利人:UNIV HONG KONG POLYTECHNIC 摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
专利号:US-10111854-B2 优先权日:2014-02-26 标题 :Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents 发明人:CHOW LARRY MING-CHEUNG; Chan Tak Hang William; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU 权利人:UNIV HONG KONG POLYTECHNIC 摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
专利号:US-9061984-B2 优先权日:2008-08-15 标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases 发明人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM 权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS 摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
专利号:US-6797819-B1 优先权日:1998-06-11 标 题 :Alkaloids 发明人:SHAIR MATTHEW; WESTWOOD NICHOLAS; PELISH HENRY EFREM; KIRCHHAUSEN THOMAS; FENG YAN 权利人:HARVARD COLLEGE; CBR INST FOR BIOMED RES INC 摘要:The present invention provides novel alkaloid compounds and collections of these compounds, and provides methods for the synthesis of these compounds using biomimetic synthetic strategies. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as bacterial infections, proliferative diseases, and reproductive disorders, to name a few.
参考文献:10.3341/kjo.2010.24.1.40 摘要:Yaghoobi R, Maraghi S, Bagherani N, Rafiei A. Cutaneous leishmaniasis of the lid: a report of nine cases. Korean J Ophthalmol. 2010 Feb;24(1):40–3. 参考文献:10.1016/j.exppara.2011.06.016 摘要:dos Santos AO, Costa MA, Ueda-Nakamura T, Dias-Filho BP, da Veiga-Júnior VF, de Souza Lima MM, Nakamura CV. Leishmania amazonensis: effects of oral treatment with copaiba oil in mice. Exp Parasitol. 2011 Oct;129(2):145–51. doi: 10.1016/j.exppara.2011.06.016. 参考文献:10.1097/dad.0b013e31820977d1 摘要:Quintella LP, Cuzzi T, de Fátima Madeira M, Valete-Rosalino CM, de Matos Salgueiro M, de Camargo Ferreira e Vasconcellos E, Mouta-Confort E, Lambert Passos SR, de Oliveira Schubach A. Cutaneous leishmaniasis with pseudoepitheliomatous hyperplasia simulating squamous cell carcinoma. Am J Dermatopathol. 2011 Aug;33(6):642–4. doi: 10.1097/dad.0b013e31820977d1.