CAS: 35674-27-2; 4-Iodo-3-Nitrobenzoic Acid

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CAS号1588-83-6 4-氨基-3-硝基苯甲酸 | CAS号619-58-9 对碘苯甲酸 | CAS号15164-44-0 4-碘苯甲醛 | CAS号7697-37-2 硝酸 | CAS号412947-54-7 3-氨基-4-碘苯甲酸甲酯 | CAS号51411-81-5 3-氨基-4-碘苯甲酸 | CAS号89976-27-2 4-碘-3-硝基苯甲酸甲酯 | CAS号160003-66-7 4-碘-3-硝基-苯甲酰胺 | CAS号82408-83-1 乙基9H-咔唑-2-羧酸酯 | CAS号57362-77-3 4-碘-3-硝基苯甲酸乙酯 | CAS号51094-28-1 9H-咔唑-2-羧酸

4-碘-3-硝甲苯置于chromium(Vi) Oxide,氧气,高碘酸体系中,用 乙腈 作为反应溶剂,60.0 °C,101.33 Kpa 条件下,以23%的收率获得产物4-碘-3-硝基苯甲酸
参考文献:廉价的nax(x = I,Br,Cl)作为有氧条件下实际的ag / Cu介导的芳基羧酸脱羧卤化反应中的卤素供体†
标题:廉价的nax(x = I,Br,Cl)作为有氧条件下实际的ag / Cu介导的芳基羧酸脱羧卤化反应中的卤素供体†
摘要:在好氧条件下,中等到非常好的收率已经实现了易于获得的芳基羧酸与丰富的nax(x = I,Br,Cl)之间的多功能且实用的ag / Cu介导的脱羧卤化反应.对于在邻位具有硝基,氯和甲氧基取代基的含s的杂芳族羧酸和苯甲酸,表明卤代羧化是一种有效的策略.已经进行了克级反应和三步合成iniparib的过程,以评估该协议的实用性.初步的机械研究表明,Cu起着至关重要的作用,并且自由基途径参与了转变.
DOI:10.1039/c8Ob01095A

专利信息

专利号:US-2022143183-A1
优先权日:2019-02-23
标题:Photoswitchable protacs and synthesis and uses thereof
发明人：TRAUNER DIRK; REYNDERS MARTIN; MATSUURA BRYAN; BEROUTI MARLEEN; PAGANO MICHELE
权利人:UNIV NEW YORK
摘要:Provided are compounds, which may be referred to as PHOTACs (photoswitchable proteolysis targeting chimeras), and compositions, kits, and methods of making and using PHOTACs. PHOTACs have one or more E3 ligase ligand(s), one or more photoswitchable group(s), optionally, one or more linker(s), and one or more ligand(s) for a target protein. PHOTACs may be suitable for use in methods to treat diseases, such as, for example, cancer. PHOTACs may also be suitable for use in methods to induce selective degradation of a target protein.