CAS: 460-08-2; 2-Fluoroethanamine Hydrochloride

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354-38-1 815-06-5 7387-69-1

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CAS号33021-75-9 3-(2-fluoroethy... | CAS号33021-91-9 3-(2-fluoroethy... | CAS号122974-04-3 BENZYL-(2-FLUOR... | CAS号13907-93-2 1-(2-chloroethy... | CAS号505-12-4 1-Fluoro-2-is°C...

2-氟乙醇置于对甲苯磺酰氯,Potassium Phtalimide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 5.5H,反应生成 2-氟乙胺盐酸盐
参考文献:2-氟乙胺盐酸盐的制备方法
标题:2-氟乙胺盐酸盐的制备方法
摘要:本发明涉及2‑氟乙胺盐酸盐的一种制备方法,其特点是,采用2‑氟乙醇与甲苯磺酰氯的参与反应,能采用常规的氮气排除反应液中的氯化氢气体,避开了萃取的等操作,免去萃取的采用.并且,优化了整体的反应时间,提高设备利用率.更为重要的是,通过乙醇和水提取除杂技术,不仅得到的产品含量高(99%),而且收率提高了,且两者不仅原料价格便宜,易得,无污染.由此,在减少成本的同时,极大的增加了最终物的产出.

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-5985844-A
优先权日:1992-03-26
标题:Homoerythromycin A derivatives modified at the 4'-and 8A-positions
发明人：HECK JAMES V; LEANZA WILLIAM J; RATCLIFFE RONALD W; SALZMANN THOMAS N; SHANKARAN KOTHANDARAMAN; SZYMONIFKA MICHAEL J; WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:Compounds of the formula: where R is hydrogen, hydroxyl, alkyl or acyl, R' and R'' together are oxo, hydroxyimino or alkoxyimino, and R' and R'' independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products