CAS: 52286-59-6; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethyl-17-((S)-6-Methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Hept-5-En-2-yl)Hexadecahydro-1H-Cycl

该化合物是一种天然化合物,主要存在于人参物种中,特别是Panax 人参,主要存在于人参物种中,主要存在于人参物种中;其结构复杂,包括一种带有多种糖糖糖的类固醇脊椎,有助于其生物活性; 蛋蛋蛋色沙底具有各种药理特性,包括抗炎,抗氧化剂和...

英文名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethyl-17-((S)-6-Methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Hept-5-En-2-yl)Hexadecahydro-1H-Cycl
中文名称人参皂苷RE
IUPAC名称(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
其它别名Chikusetsusaponin Ivc; Ginsenoside B2; 18:1 Trans-11; (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-Dihydroxydammar-24-En-6-Yl 2-O-6-Deoxy-α-L-Mannopyranosyl-β-D-Glucopyranoside; Sanchinoside Re; Panaxosid
CAS编号52286-59-6
MFCD编号:MFCD00133369
EINECS号:257-814-6
FDA UNII编号:46F3R0BL3I
分子式:C48H82O18
分子量:947.17
产品CID: 2498348
产品分类生物化工 → 提取物

相似结构搜索
产品信息参考;;;;
InChIKey: PWAOOJDMFUQOKB-WCZZMFLVSA-N
InChI=1S/C48H82O18/c1-21(2)11-10-14-48(9,66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4,5)40(4…
计算化学: 氢键受体数18.0氢键供体数12.0可旋转键数12.0

物理性质

熔点202 °C (分解)
沸点1011.8±65.0 °C at 760 mmHg
闪点565.7±34.3 °C
密度1.4±0.1 g/cm3
pKa:12.85±0.70(预测)
PSA:298.14
LogP:4.75
折射率1.611
蒸汽压0.0±0.6 mmHg at 25°C
溶解性DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
敏感性如果遵照规格使用和储存则不会分解，未有已知危险反应
外观形态白色至类白色固体
储存条件惰性气氛,2-8°C

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号53963-43-2 人参皂苷 F1 | CAS号492-61-5 β-D-葡萄糖 | CAS号6014-42-2 鼠李糖 | CAS号22427-39-0 人参皂苷Rg1 | CAS号80952-71-2 (20R)-人参皂苷Rh1

合成工艺路线路线简述

专利信息

专利号:US-7811612-B2
优先权日:2005-01-20
标题 :Herbal mixture extract of notoginseng radix, rehmanniae radix preparata and acanthopanacis cortex and composition comprising the same for prevention and treatment of arthritis
发明人：KIM JUNG-KEUN; KIM SE-WON; KIM HYUNG-GUN; KO SEON-YLE; BAEK DONG-HEON; CHANG SUNHWA
权利人:OSCOTEC INC
摘要:The present invention relates to an extract of an herbal mixture of Notoginseng radix, Rehmanniae radix preparata and Acanthopanacis cortex , and a method for treating arthritis using the extract as an effective ingredient. The extract of the herbal mixture of the present invention can effectively inhibits the release of inflammatory substances and the synthesis of cartilage destroying substance as well as the progress of arthritis.

专利号:CN-114058628-A
优先权日:2021-10-11
标题 :Gene PnWRKY1 and its application in regulating the synthesis of Panax notoginseng saponins

专利号:CN-114836398-A
优先权日:2022-06-06
标题 :Application of glycosyltransferase mutants in the directed synthesis of unnatural ginsenosides

专利号:CN-114836398-B
优先权日:2022-06-06
标题:Application of Glycosyltransferase Mutants in Directed Synthesis of Unnatural Ginsenosides

专利号:CN-114058627-A
优先权日:2021-10-11
标题:Gene PnMYB2 and application thereof in regulating and controlling synthesis of notoginsenoside

专利号:CN-114058632-A
优先权日:2021-10-11
标题:Gene PnCOX11 and its application in regulating the synthesis of Panax notoginseng saponins

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主要参考文献

1: Nam Y, Wie MB, Shin EJ, Nguyen TT, Nah SY, Ko SK, Jeong JH, Jang CG, Kim HC. Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH-SY5Y cell lines. J Appl Toxicol. 2015 Aug;35(8):927-44. doi: 10.1002/jat.3093. Epub 2014 Dec 18. doi: 10.1055/s-0034-1382959. Epub 2014 Sep 8. doi: 10.1016/j.lfs.2014.09.007. Epub 2014 Sep 19. doi: 10.1007/s10571-015-0177-7. Epub 2015 Mar 17. doi: 10.1021/jf5000776. Epub 2014 Mar 25. doi: 10.14348/molcells.2016.0111. Epub 2016 Dec 6.
7: Shin EJ, Shin SW, Nguyen TT, Park DH, Wie MB, Jang CG, Nah SY, Yang BW, Ko SK, Nabeshima T, Kim HC. Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene. Mol Neurobiol. 2014 Jun;49(3):1400-21. doi: 10.1007/s12035-013-8617-1. Epub 2014 Jan 16. doi: 10.1016/j.jgr.2013.10.001. Epub 2013 Dec 18.
9: Kim JH, Han IH, Yamabe N, Kim YJ, Lee W, Eom DW, Choi P, Cheon GJ, Jang HJ, Kim SN, Ham J, Kang KS. Renoprotective effects of Maillard reaction products generated during heat treatment of ginsenoside Re with leucine. Food Chem. 2014 Jan 15;143:114-21. doi: 10.1016/j.foodchem.2013.07.075. Epub 2013 Jul 27. doi: 10.1016/j.intimp.2014.03.008. Epub 2014 Mar 25. doi: 10.1016/j.ejphar.2016.11.006. Epub 2016 Nov 10. doi: 10.1016/j.jchromb.2014.10.025. Epub 2014 Oct 27. doi: 10.1016/j.foodchem.2012.12.004. Epub 2012 Dec 8. doi: 10.1016/j.jep.2013.03.057. Epub 2013 Mar 30. doi: 10.1016/j.foodchem.2012.09.050. Epub 2012 Sep 21. doi: 10.1016/j.jgr.2015.02.004. Epub 2015 Mar 6.

合成参考文献

摘要:Arzneimittel-Forschung. Drug Research., 25(539), 1975 []
参考文献:10.1016/0959-8049(96)00102-5
摘要:Lee YN, Lee HY, Chung HY, Kim SI, Lee SK, Park BC, Kim KW. In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. Eur J Cancer. 1996 Jul;32A(8):1420–8. doi: 10.1016/0959-8049(96)00102-5.
参考文献:10.1038/sj.bjp.0705814
摘要:Bai C, Takahashi K, Masumiya H, Sawanobori T, Furukawa T. Nitric oxide‐dependent modulation of the delayed rectifier K⁺ current and the L‐type Ca²⁺ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea‐pig cardiomyocytes. British J Pharmacology. 2004 Jun;142(3):567–75. doi: 10.1038/sj.bjp.0705814.
参考文献:10.1007/s00709-017-1081-4
摘要:Silva J, Kim YJ, Xiao D, Sukweenadhi J, Hu T, Kwon WS, Hu J, Yang DC, Zhang D. Cytological analysis of ginseng carpel development. Protoplasma. 2017 Sep;254(5):1909–22. doi: 10.1007/s00709-017-1081-4.
参考文献:10.1021/jf030042h
摘要:Assinewe VA, Baum BR, Gagnon D, Arnason JT. Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng). J Agric Food Chem. 2003 Jul 30;51(16):4549–53. doi: 10.1021/jf030042h.

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CAS: 52286-59-6; (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethyl-17-((S)-6-Methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Hept-5-En-2-yl)Hexadecahydro-1H-Cycl

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

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