专利号:US-2011263720-A1 优先权日:2010-03-09 标 题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same 发明人:PAISLEY STEVEN D; LEPREE JASON M; HAWI AMALE; ECKHOFF MICHAEL 权利人:PENWEST PHARMACEUTICALS CO 摘要:The present invention is directed to a method of synthesizing a compound of Formula I: n n n n n n n n n n the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.
专利号:US-8895760-B2 优先权日:2010-02-26 标 题 :Process for the preparation of L-lactide of high chemical yield and optical purity 发明人:IDAGE BHASKAR BHAIRAVNATH; IDAGE SUSHEELA BHASKAR; SWAMINATHAN SIVARAM 权利人:IDAGE BHASKAR BHAIRAVNATH; IDAGE SUSHEELA BHASKAR; SWAMINATHAN SIVARAM; COUNCIL SCIENT IND RES 摘要:A process for the synthesis of 100% optically pure L(+)-lactide catalyzed by zinc and tin metal catalysts of less than 150 micron particle size is disclosed. The L-lactide obtained was further purified to obtain lactide of 100% optical purity and acid impurities less than 10 meq/kg.
专利号:US-2011269201-A1 优先权日:2010-04-30 标题:Redirected bioenergetics in recombinant cellulolytic clostridium microorganisms 发明人:GRAY KEVIN; O'MULLAN PATRICK 权利人:QTEROS INC 摘要:Compositions and methods are provided for redirecting metabolic solventogenesis pathways to enhance the product yield from fermentation of biomass. Clostridium microorganism pathways are modified to extend the growth phase and prevent inhibition of acetaldehyde while bypassing the synthesis of acetyl CoA.
专利号:WO-2011112679-A1 优先权日:2010-03-09 标题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
专利号:WO-2013160485-A1 优先权日:2012-04-28 标 题 :Process for continuous preparation of lactide directly from concentrated lactic acid 发明人:HOELDERLICH WOLFGANG; VENSCHOTT MORITZ 权利人:UHDE INVENTA FISCHER GMBH 摘要:The subject-matter of the present invention relates to a process for the continuous, heterogeneously catalysed, direct preparation of L-lactide from concentrated lactic acid. The aim is to circumvent the process steps of the known prepolymerization and subsequent depolymerization, and to reduce them to one synthesis step. Furthermore, the by-products and the racemization are minimized, and so high-purity L-lactide is prepared.
专利号:WO-9846763-A1 优先权日:1997-04-11 标题:Methods and compositions for synthesis of long chain polyunsaturated fatty acids