CAS: 85068-30-0; 1-(2,4-Difluorophenyl)Propan-1-One

该化合物是一种有机化合物,其特征是氯酮功能组和二氟苯替代物,这种化合物一般是无色的,光黄色液体或固体,视其纯度和温度而定;其分子式反映一个联苯环上有一个配有两个氟原子的丙酮脊椎,在2和4个位置上取而代之.氟原子的存在往往会增强化合物的脂质,并影响其回流性和稳定性.这种物质在各个领域都有意义,包括制药和农用化学品,因为它在合成中和化学反应中的潜在应用.其物理特性,如沸点,熔点和溶性,可以根据样品的具体条件和纯度而变化.处理和储存时,应当参考安全数据,如任何化学物质一样.

英文名称1-(2,4-Difluorophenyl)Propan-1-One
中文名称2',4'-二氟苯丙酮
IUPAC名称1-(2,4-difluorophenyl)propan-1-one
其它别名2,4-二氟苯丙酮; 2',4'-Difluoropropiophenone
CAS编号85068-30-0
MFCD编号:MFCD00015507
EINECS号:285-291-4
分子式:C9H8F2O
分子量:170.16
产品CID: 1843866
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考
InChIKey: UZWOADNMVRRYDE-UHFFFAOYSA-N
InChI=1S/C9H8F2O/c1-2-9(12)7-4-3-6(10)5-8(7)11/h3-5H,2H2,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P210-P264-P280-P302+P352-P362-P501
危险等级IRRITANT
UN编号UN 3276
危险品标志Xi,T
风险等级Toxic
安全声明37/39-26-36-36/37-36/37/39
危险类别码36/37/38-36/37

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号372-18-9 1,3-二氟苯 | CAS号79-03-8 丙酰氯 | CAS号224048-17-3 1-环己基-3-乙基-6-氟-1H-吲唑

合成工艺路线路线简述

2267-47-2 = 85068-30-0 + 123184-17-8
反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Iridium(1+),Chloro[2-(4,5-Dihydro-1H-Imidazol-2-Yl-Kn3)-5-Methoxypyridine-Kn][(... Solvents: Water; 10 H,80 °C
标题:Iridium Complexes As Efficient Catalysts For Construction Of α-Substituted Ketones Via Hydrogen Borrowing Of Alcohols In Water
作者:Luo,Nianhua; Zhong,Yuhong; Wen,Huiling; Shui,Hongling; Luo,Renshi
参考文献:European Journal Of Organic Chemistry 日期:2021 卷标:2021(9) 页码:1355-1364]

4637-24-5 + 364-83-0 = 85068-30-0
反应条件:1.1 24 H,120 °C1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 12 H,Rt
标题:Dmf Dimethyl Acetal As Carbon Source For α-Methylation Of Ketones: A Hydrogenation-Hydrogenolysis Strategy Of Enaminones
作者:Borah,Ashwini; Goswami,Limi; Neog,Kashmiri; Gogoi,Pranjal
参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(9) 页码:4722-4728]

= 85068-30-0
反应条件:1.1 Catalysts: Aluminum Chloride
标题:Design,Synthesis And Antifungal Activity Of Novel Triazole Derivatives With Piperazine Side Chain
作者:Xu,Bo; Shi,Yuan; Zhang,Wan-Nian; Sheng,Chun-Quan
参考文献:Yaoxue Shijian Zazhi 日期:2013 卷标:31(3) 页码:176-180

1-(2,4-Difluorophenyl)-3-(Dimethylamino)Prop-2-En-1-One置于palladium 10% On Activated Carbon,氢气体系中,用乙醇作为反应溶剂,化学反应 12.0H,以110 Mg的收率获得产物2,4-二氟苯丙酮
参考文献:Dmf Dimethyl Acetal As Carbon Source For α-Methylation Of Ketones: A Hydrogenation-hydrogenolysis Strategy Of Enaminones
标题:Dmf Dimethyl Acetal As Carbon Source For α-Methylation Of Ketones: A Hydrogenation-hydrogenolysis Strategy Of Enaminones
摘要:A Novel Heterogeneous Catalytic Hydrogenation Hydrogenolysis Strategy Has Been Developed For The Alpha-Methylation Of Ketones Via Enaminones Using Dmf Dimethyl Acetal As Carbon Source. This Strategy Provides A Very Convenient Route To Alpha-Methylated Ketones Using A Variety Of Ketones Without Any Base Or Oxidant.
DOI:10.1021/acs.Joc.5B00084

海关参考信息

2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2912210000-苯甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:RU-2190606-C2
优先权日:1997-11-04
标题:Methods of synthesis of 4-cyano-4-(substituted indazole)-cyclohexane carboxylic acid esters used as inhibitors of phosphodiesterase 4 (pde 4) and intermediate compounds for their synthesis

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:RU-2039050-C1
优先权日:1989-09-26
标题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis