CAS: 923-61-5; (2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Dipalmitate

相似化合物

998-07-2 1069-79-0 4004-05-1

上下游产品

CAS号59540-20-4 2-(1',2'-dipalm... | CAS号57818-60-7 hexadecanoic ac... | CAS号30334-71-5 1,2-双棕榈酸甘油酯

(R)-3-(((2-(Fluorenylmethoxycarbonylamino)Ethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Dipalmitate置于1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以78%的收率获得产物l-磷脂酰乙醇胺
参考文献:1,2-二棕榈酰-Sn-甘油-3-磷酰乙醇胺及其制备方法
标题:1,2-二棕榈酰-Sn-甘油-3-磷酰乙醇胺及其制备方法
摘要:本发明提供一种1,2‑二棕榈酰‑sn‑甘油‑3‑磷酰乙醇胺及其制备方法,其中制备方法包括如下步骤:步骤s1,二棕榈酸甘油酯在四氢呋喃和碱的作用下,与pocl3发生亲核取代反应,在反应完成后对反应产物进行纯化,得到中间体1,所述中间体1为(R)‑3‑((二氯磷酰基)氧基)丙烷‑1,2‑二棕榈酸;步骤s2,所述中间体1在四氢呋喃和碱的作用下,与n‑fmoc‑乙醇胺发生亲核取代反应,在反应完成后对反应产物进行纯化,得到中间体2,所述中间体2为(R)‑3‑(((2‑(芴甲氧羰氨基)乙氧基)(羟基)磷酰基)氧基)丙烷‑1,2‑二棕榈酸酯;步骤s3,所述中间体2在溶剂和碱作用下,发生亲核取代反应,得到所述1,2‑二棕榈酰‑sn‑甘油‑3‑磷酰乙醇胺.根据本发明实施例的制备方法,最终产物纯度较高,副产物少.

专利信息

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-2011195450-A1
优先权日:2005-09-27
标 题 :In Vitro Protein Synthesis Systems for Membrane Proteins that Include Adolipoproteins and Phospholipid Adolipoprotein Particles
发明人：KUDLICKI WIESLAW; FLETCHER JULIA; KATZEN FEDERICO
权利人:LIFE TECHNOLOGIES CORP
摘要:In vitro protein synthesis systems and methods are provided that produce membrane proteins in soluble form. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include an apolipoprotein, in which higher yields of soluble protein are produced than in the absence of the apolipoprotein. Apolipoproteins useful in the present invention include naturally occurring apolipoproteins, as well as sequence variants of wild-type apolipoproteins, and engineered apolipoproteins. The apolipoproteins can be provided in an in vitro protein synthesis system associated with lipid or not associated with lipid. The invention also provides compositions and kits for synthesis of proteins in soluble form, in which the compositions and kits include cell extracts for protein translation and at least one apolipoprotein biomolecule.

专利号:WO-2007038755-A1
优先权日:2005-09-27
标 题:In vitro protein synthesis systems for membrane proteins that include apolipoproteins and phospholipid-apolipoprotein particles
发明人：KUDLICKI WIESLAW; FLETCHER JULIA; KATZEN FEDERICO
权利人:INVITROGEN CORP; KUDLICKI WIESLAW; FLETCHER JULIA; KATZEN FEDERICO
摘要:In vitro protein synthesis systems and methods are provided that produce membrane proteins in soluble form. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include an apolipoprotein, in which higher yields of soluble protein are produced than in the absence of the apolipoprotein. Apolipoproteins useful in the present invention include naturally occurring apolipoproteins, as well as sequence variants of wild-type apolipoproteins, and engineered apolipoproteins. The apolipoproteins can be provided in an in vitro protein synthesis system associated with lipid or not associated with lipid. The invention also provides compositions and kits for synthesis of proteins in soluble form, in which the compositions and kits include cell extracts for protein translation and at least one apolipoprotein biomolecule.

专利号:US-6217901-B1
优先权日:1999-05-25
标题:Liposome-assisted synthesis of polymeric nanoparticles
发明人：PERROTT MICHAEL G; BARRY STEPHEN E
权利人:ALNIS LLC
摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.

专利号:US-9932582-B2
优先权日:2014-01-14
标题 :Materials and methods for modulation of tendon healing
发明人：GILCHRIST DEREK STEWART; MILLAR NEAL LINDSAY
权利人:UNIV GLASGOW COURT
摘要:The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favor of type 1 collagen, mitigating reduction in biomechanical properties during healing.