CAS: 138423-98-0; (3-Formylindol-1-yl)Acetic Acid

相似化合物

363590-49-2 134903-41-6 351015-73-1

上下游产品

CAS号27065-94-7 (3-甲酰基-1H-吲哚-1-... | CAS号363590-49-2 1H-INDOLE-1-ACE... | CAS号487-89-8 3-吲哚甲醛 | CAS号120-72-9 吲哚 | CAS号7748-25-6 potassium mon°C...

3-吲哚甲醛置于氢气,Sodium Hydride,三氟乙酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 17.0H,反应生成N-乙酸-3-吲哚甲醛
参考文献:终端脱氧核苷酸转移酶的新型核苷酸竞争性非核苷抑制剂:发现,表征和晶体结构与目标复杂.
标题:终端脱氧核苷酸转移酶的新型核苷酸竞争性非核苷抑制剂:发现,表征和晶体结构与目标复杂.
摘要:末端脱氧核糖核酸转移酶(tdt)在某些类型的癌症中过表达,在通过非同源末端连接(nhej)途径诱变修复双链断裂(dsb)的过程中,末端脱氧核糖核酸转移酶可能与polμ竞争.在这里我们报告发现和表征的吡咯基和吲哚基二酮酸,专门针对tdt和表现为核苷酸竞争性抑制剂.与hela细胞相比,这些化合物对molt-4具有选择性毒性,而hela细胞与tdt的体外选择性密切相关.通过与tdt共结晶确定了这两种抑制剂的结合位点,从而解释了为什么这些化合物是脱氧核苷酸三磷酸(dntp)的竞争性抑制剂.此外,由于观测到的苯基取代基的双重定位,
Doi:10.1021/jm4010187

专利信息

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:WO-03068806-A1
优先权日:2002-02-14
标 题 :Solid phase peptide synthesis on silica
发明人：GROARKE MICHELLE
权利人:JOHNSON MATTHEY PLC; GROARKE MICHELLE
摘要:A method for peptide synthesis is described, comprising steps of forming an organofunctional silica by reaction of an alkyl silicate, an organofunctional silane and water, optionally in the presence of a template compound; removing the template compound if present; reacting said organofunctional silica with a first protected amino acid to produce a tethered protected amino acid; deprotecting the tethered protected amino acid; reacting at least one further protected amino acid with said tethered deprotected amino acid to form a tethered peptide, and removing the peptide from the organofunctional silica. Preferably, prior to reaction of the first protected amino acid, the organofunctional silica is reacted with at least one linking compound to form a linker-modified organofunctional silica with which the first protected amino acid is reacted. A method for preparing an organfunctional silica by the co-hydrolysis of an alkyl silicate and an organofunctional silane is depicted below. The wavy line represents the silicon atom on or within the resulting silica material formula (I). A reaction of a protected amino acid with an organofunctional silica to provide a tethered protected amino acid is depicted below formula (II).

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.

专利号:US-9688980-B2
优先权日:2001-06-20
标 题 :Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; FRANCH THOMAS; SAMS CHRISTIAN KLARNER; OLSEN EVA KAMPMANN; SLOK FRANK ABILGAARD; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; HYLDTOFT LENE; NORREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRODER; THISTED THOMAS; FRESKGARD PER-OLA; HOLTMANN ANETTE
权利人:NUEVOLUTION AS; NUEVOLUTION
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.

专利号:JP-H1067724-A
优先权日:1996-04-08
标 题 :Resin for chemical synthesis having improved functional group and production of amide-based compound using the same