CAS: 27757-86-4; 3-(Aminomethyl)Thiophene

上下游产品

CAS号1641-09-4 3-氰基噻吩 | CAS号498-62-4 3-噻吩甲醛

3-噻吩甲酰氯置于ammonium Hydroxide,Lithium Aluminium Tetrahydride体系中,用 四氢呋喃,二氯甲烷,水 用作溶剂,化学反应 5.0H,反应生成3-氨甲基噻吩
参考文献:设计和合成基于杂芳基的苯磺酰胺衍生物作为h5N1甲型流感病毒的有效抑制剂†
标题:设计和合成基于杂芳基的苯磺酰胺衍生物作为h5N1甲型流感病毒的有效抑制剂†
摘要:甲型流感病毒是一种包膜的负性单链rna病毒,可引起发热的呼吸道感染,对人类健康乃至全世界的生命都构成了具有临床挑战性的威胁.更令人震惊的是高致病性禽流感(hpai)菌株(如h5N1)的出现,其在人类感染中的死亡率(60%)比季节性流感菌株高得多.在这项研究中,新的杂芳基苯磺酰胺衍生物系列被确定为m2质子通道抑制剂.对结构-活性关系的系统研究和分子对接研究表明,磺酰胺部分和2,5-二甲基取代的噻吩作为核心结构在抗流感活性中起着重要作用.在衍生物中,化合物11K具有对h5N1病毒的优异抗病毒活性,Ec 50值为0.47μm,选择性指数为119.9,与参考药物金刚烷胺相当.
Doi:10.1039/c8Md00474A

专利信息

专利号:US-9458115-B2
优先权日:2009-04-20
标 题 :Synthesis of substituted pyrazines
发明人：PAGORIA PHILIP F; ZHANG MAO XI
权利人:PAGORIA PHILIP F; ZHANG MAO XI; L LIVERMORE NAT SECURITY LLC
摘要:A method for synthesizing a pyrazine-containing material according to one embodiment includes contacting an iminodiacetonitrile derivative with a base and a reagent selected from a group consisting of hydroxylamine, a hydroxylamine salt, an aliphatic primary amine, a secondary amine, an aryl-substituted alkylamine a heteroaryl-substituted alkyl amine, an alcohol, an alkanolamine and an aryl alcoholamine. Additional methods and several reaction products are presented.

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:US-4086423-A
优先权日:1973-10-12
标题 :Process for cephem synthesis
发明人：FIRESTONE RAYMOND A; RATCLIFFE RONALD W; CHRISTENSEN BURTON G
权利人:MERCK & CO INC
摘要:Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##

专利号:US-2023023607-A1
优先权日:2020-02-06
标题 :Methods for practical synthesis of deuterated amino acids

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.