CAS: 360-65-6; Glycodeoxycholic Acid

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CAS号56-40-6 甘氨酸 | CAS号83-44-3 去氧胆酸 | CAS号2287-93-6 Cholan-24-oic a... | CAS号86678-83-3 3α,12α-diformyl...

去氧胆酸置于盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺,聚甘氨酸体系中,用 二氯甲烷,二甲基亚砜 用作溶剂,化学反应 8.0H,反应生成甘氨脱氧胆酸
参考文献:Synthesis,Anticancer Activities,Antimicrobial Activities And Bioavailability Of Berberine-Bile Acid Analogues
标题:Synthesis,Anticancer Activities,Antimicrobial Activities And Bioavailability Of Berberine-Bile Acid Analogues
摘要:合成了十五种小檗碱-胆酸类似物.与小檗碱(bbr)相比,这些类似物的抗癌活性在体外进行了评估;在这些类似物中,A4,B4 和 B5 的细胞毒性高于 Bbr.大多数类似物对金黄色葡萄球菌 Atcc 25923 和白色念珠菌 Atcc 8799 具有较高的抗菌活性,而对枯草芽孢杆菌 As 1.398 和大肠杆菌 Atcc 31343 则无敏感性.A4 和 B4 在血清稳定性实验中表现出稳定性.B4 在小鼠中显示出非常好的口服生物利用度.
Doi:10.2174/157018012800673010

专利信息

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2006211083-A1
优先权日:2005-01-21
标题:Products and processes for in vitro synthesis of biomolecules
发明人：KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.

专利号:US-9828445-B1
优先权日:2016-12-13
标题:Synthesis of modified chitosan particles for oral insulin delivery
发明人：ATTA AYMAN M; AL-LOHEDAN HAMAD A; EZZAT ABDELRAHMAN O
权利人:UNIV KING SAUD
摘要:Synthesis of modified chitosan particles for oral insulin delivery includes amidation of chitosan with a fatty acid, a modified fatty acid, and/or an amino acid. The amidated chitosan can be grafted with N-isopropylacrylamide (NIPAm) and cross-linked to provide the modified chitosan particles.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6638498-B2
优先权日:2000-06-30
标题:Molecularly imprinted polymers for the treatment and diagnosis of medical conditions
发明人：GREEN BERNARD S; PRIWLER MORRIS
权利人:SEMOREX INC
摘要:Improved molecularly imprinted polymers (MIPs) with both higher and more specific binding capacity for particular bile acids and/or salts, including the synthesis of such MIPs, the compounds themselves, and specific applications thereof. As an example of a particularly preferred specific application of these compounds, the present invention encompasses the use of the MIPs as sequestrants in the gastrointestinal tract, particularly in order to bind and therefore remove toxins from the gastrointestinal tract. In addition, the present invention is also useful for treatment of various diseases which are related to, and/or characterized by, an effect of bile acids and salts, such as atherosclerosis, liver disease and various diseases of the gastrointestinal tract. The MIP compounds of the present invention are also useful for combination therapy with other medications and for diagnosis and monitoring of diseases.