CAS: 4395-73-7; (4-Isopropylphenyl)Methanamine

上下游产品

CAS号1202873-21-9 1-isopropyl-4-m... | CAS号122-03-2 枯名醛 | CAS号53515-20-1 4-异丙基苯硫代羧胺 | CAS号859441-41-1 N-(4-isopropyl-... | CAS号2051-18-5 4-异丙基苄氯 | CAS号10407-16-6 1-(4-isopropylb... | CAS号13816-33-6 4-异丙基苯甲腈 | CAS号7647-01-0 盐酸 | CAS号64-17-5 乙醇

4-异丙基苯甲醛置于氨,氢气体系中,用 Aq. Buffer 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,以98%的收率获得产物4-异丙基苄胺
参考文献:使用 ω-转氨酶和镍基纳米催化剂对外消旋胺进行脱消旋
标题:使用 ω-转氨酶和镍基纳米催化剂对外消旋胺进行脱消旋
摘要:手性胺是开发众多生物活性化合物的关键组成部分.在这项研究中,我们开发了一种使用 ω-转氨酶的并发化学酶级联方法,用于外消旋胺混合物的异构构型反转.一种异构体使用 ω-转氨酶转氨,反应生成联产物酮和一种额外的手性物质.然后,使用专门设计的相容性镍基纳米催化剂对酮进行选择性还原胺化,将副产物酮转化为外消旋胺,同时保持相反的对映异构体不变.一个反应体系中两个步骤的组合起到了整体异构构型转化体系的作用.此外,形成了具有额外手性物质的所需手性胺.该程序消耗了 Nh3并产生 H2O 作为唯一的副产物.
DOI:10.1021/acscatal.2C03362

专利信息

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-8017768-B1
优先权日:1990-09-01
标题:Catalitic synthesis of caged polynitramine compounds
发明人：NORRIS WILLIAM P; NIELSEN ARNOLD T
权利人:US NAVY
摘要:An improved method of preparing 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.0 5,9 .0 3,11 ]dodecane) (HNIW) is disclosed. The compound is useful as a high energy, high density explosive or propellant oxidizer.

专利号:US-4734495-A
优先权日:1985-07-17
标 题 :Process and intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:WO-2024077009-A1
优先权日:2022-10-03
标题 :Functionalized macromolecules and systems, methods of synthesis, and uses thereof
发明人：XIA HONGWEI; O'BRIEN EVAN; FABER-RICO JACOB; STOLARCZYK CRAIG; SIDDIQUI ASIM; YASUN EMIR; HOSSEINI NASSAB NILOUFAR
权利人:SEER INC
摘要:Disclosed herein are macromolecules, compositions thereof, and methods of making the same. In one aspect, the macromolecule are immobilized to a surface. In one aspect, provided herein are compositions, systems and kits comprising the macromolecules.

专利号:US-4870169-A
优先权日:1985-07-17
标 题:Intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.