CAS: 444-14-4; 2-Bromo-4,6-Difluoroaniline

主要参考文献

参考标题:An Approach To Spirooxindoles Via Palladium-Catalyzed Remote C-H Activation And Dual Alkylation With Ch2Br2
作者:Changdong Shao,Zhuo Wu,Xiaoming Ji,Bo Zhou,Yanghui Zhang
摘要:A Facile And Efficient Approach For The Synthesis Of Spirooxindoles Has Been Developed Via The Coupling Of Spirocyclic C, C-Palladacycles With Ch2Br2. The Key Spirocyclic Palladacycles Are Generated Catalytically Via Intramolecular Remote C-H Activation. A Range Of Spirooxindoles Can Be Synthesized In Good To Excellent Yields From Readily Available Starting Materials.

合成参考文献

摘要:Le Bras, J.; Muzart, J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 191.
摘要:Fagnoni, M.; Ravelli, D.; Protti, S., Science of Synthesis, (2020) , 342.
参考文献:10.1038/ncomms14193|10.1038/ncomms15273
摘要:Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M. Erratum: SC83288 is a clinical development candidate for the treatment of severe malaria. Nature Communications. 2017 Apr 06;8(1):15273. doi: 10.1038/ncomms15273.