CAS: 5535-48-8; (Vinylsulfonyl)Benzene

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CAS号1822-73-7 苯基乙烯基硫醚 | CAS号20451-53-0 苯基乙烯基亚砜 | CAS号20611-21-6 2-(苯基磺酰基)乙醇 | CAS号938-09-0 2-氯乙基苯基砜 | CAS号5535-49-9 2-氯乙基苯基硫醚 | CAS号963-15-5 顺-1,2-二(苯砜)乙烯 | CAS号50-00-0 甲醛 | CAS号17872-92-3 苯基三甲基硅基甲砜 | CAS号1202639-03-9 (S)-6-((2,4-din... | CAS号873-55-2 苯亚磺酸钠 | CAS号109802-71-3 buta-1,3-dien-2... | CAS号110362-32-8 acetic acid,3-(... | CAS号75-73-0 四氟化碳 | CAS号335-21-7 全氟(乙基环己胺) | CAS号355-68-0 全氟环己烷 | CAS号355-02-2 全氟(甲基环己烷) | CAS号855298-16-7 Benzene, 1-[(1E... | CAS号948-03-8 1-羟基-2-萘甲酸甲酯 | CAS号94089-47-1 (+)-(R)-3-(1-甲基... | CAS号22633-22-3 tetradecane-6,9...

2-(苯基磺酰基)乙醇置于4-二甲氨基吡啶,碳酸氢钠,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷,丙酮 作为反应溶剂,化学反应 24.0H,反应生成 苯基乙烯基砜
参考文献:π-缺陷型 2-(芳基磺酰基)乙酯作为羧酸的保护基团
标题:π-缺陷型 2-(芳基磺酰基)乙酯作为羧酸的保护基团
摘要:研发了几种 π 缺陷型 2-(芳基磺酰基)乙基作为羧酸保护基团.2-[3,5-双(三氟甲基)苯磺酰基]乙基是在温和碱性条件下使用 Nahco 3 水溶液最容易去除的酸保护基团.
DOI:10.1055/s-2003-36844

专利信息

专利号:US-8426612-B2
优先权日:2009-04-22
标 题:Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole
发明人：SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO
权利人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO; ITALIANA SINT SPA
摘要:The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.

专利号:WO-2005103035-A1
优先权日:2004-04-23
标题:Modified fischer indole synthesis of eletriptan
发明人：ASHCROFT CHRISTOPHER PAUL
权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER
摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.

专利号:EP-2647639-A1
优先权日:2012-04-06
标题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:EP-2647640-A1
优先权日:2012-04-06
标 题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-boated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:US-9006231-B2
优先权日:2008-03-03
标 题:Cephalotaxus esters, methods of synthesis, and uses thereof
发明人：GIN DAVID Y; WILMOT JEREMY; DJABALLAH HAKIM
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.

专利号:WO-2010121673-A1
优先权日:2009-04-22
标 题 :Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole