CAS: 568-72-9; 1,6,6-Trimethyl-6,7,8,9-Tetrahydrophenanthro[1,2-B]Furan-10,11-Dione

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CAS号35825-57-1 隐丹参酮 | CAS号2270-59-9 5-溴-2-甲基-2-戊烯 | CAS号578-57-4 邻溴苯甲醚 | CAS号171979-69-4 1,1-dimethyl-5-... | CAS号33214-70-9 5-methoxy-1,1-d... | CAS号100-66-3 苯甲醚 | CAS号171979-70-7 1-(1'-methoxyph... | CAS号171979-68-3 1-(5,5-dimethyl...

隐丹参酮置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 苯 作为反应溶剂,化学反应 42.0H,以91%的收率获得产物丹参酮 Iia
参考文献:Aromatic Annulation Strategy For The Synthesis Of Angularly-Fused Diterpenoid Quinones. Total Synthesis Of (+)-Neocryptotanshinone,(-)-Cryptotanshinone,Tanshinone Iia,And (.+-.)-Royleanone
标题:Aromatic Annulation Strategy For The Synthesis Of Angularly-Fused Diterpenoid Quinones. Total Synthesis Of (+)-Neocryptotanshinone,(-)-Cryptotanshinone,Tanshinone Iia,And (.+-.)-Royleanone
摘要:The Application Of A Photochemical Aromatic Annulation Strategy In Highly Efficient Total Syntheses Of Several Diterpenoid Quinones Isolated From The Traditional Chinese Medicine Dan Shen Is Reported. The Pivotal Step In Each Synthesis Involves The Assembly Of A Key Tricyclic Intermediate Via The Application Of A Recently Developed ''Second-Generation'' Photochemical Aromatic Annulation Method For The Construction Of Highly Substituted Aromatic Systems. In The Total Synthesis Of Neocrypto-Tanshinone,;The Synthesis Of The Requisite Diazo Ketone Annulation Substrate 7 Was Achieved Using Palladium-Mediated Coupling Reactions And An Intramolecular Friedel-Crafts Cyclization To Form Key Carbon-Carbon Bonds. The Pivotal Aromatic Annulation Reaction Was Then Accomplished By Irradiating A Solution Of The Diazo Ketone 7 And The Readily Available Siloxyalkyne 6 In Benzene At Room Temperature. The Desired Tricyclic Phenol 16 Was Produced In 58-65% Yield And Was Then Converted To (+)-Neocryptotanshinone (1) By Treatment With Tetra-N-Butylammonium Fluoride In The Presence Of Oxygen. Cyclization To Generate (-)-Cryptotanshinone (2) Was Accomplished In High Yield By Brief Exposure Of 1 To An Ethanolic Solution Of Concentrated Sulfuric Acid,And Dehydrogenation Of 2 With Ddq Furnished Tanshinone Iia (3). As A Further Demonstration Of The Utility Of The Photochemical Aromatic Annulation Strategy In The Construction Of Angularly-Fused Diterpenes,The Total Synthesis Of(+/-)-Royleanone (4) Was Also Investigated. Irradiation Of A Solution Of The Diazo Ketone 18 And Siloxyalkyne 25 Produced The Tricyclic Intermediate 26,Which Was Converted In Two Steps To Royleanone By Desilylation And Oxidation.
DOI:10.1021/jo00131A006

专利信息

专利号:US-11306157-B2
优先权日:2018-12-21
标 题:Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
发明人：HSIEH-WILSON LINDA C; PAWAR NITIN J; WANG LEI
权利人:CALIFORNIA INST OF TECHN
摘要:Methods for the preparation of oligosaccharide products from polysaccharide starting materials are disclosed. The methods include: hydrolyzing a glucosamine-containing polysaccharide starting material, such as heparin or heparosan, under conditions sufficient to form an oligosaccharide intermediate (e.g., a GlcN-IdoA disaccharide intermediate or a GlcA-GlcN disaccharide intermediate), and converting the oligosaccharide intermediate to the oligosaccharide product. Conversion of the oligosaccharide intermediates to the oligosaccharide products may include one or more esterification, acylation, epimerization, protection, and deprotection steps. Preparation of higher-order oligomers is described, as well as methods for selective oligosaccharide sulfation.

专利号:CN-112574892-A
优先权日:2020-12-14
标题:Mucor peregrine for promoting root development of Salvia miltiorrhiza and synthesis of tanshinone and use thereof

专利号:CN-110438011-B
优先权日:2019-07-30
标题:Cladosporium tenuissimum and application thereof in promoting synthesis of effective components of root system of salvia miltiorrhiza

专利号:CN-104341482-A
优先权日:2013-08-09
标 题 :Synthesis of a Heterocyclic Sulfonic Acid Derivative and Its Application in Drug Therapy

专利号:CN-104341482-B
优先权日:2013-08-09
标题 :Synthesis of a Heterocyclic Sulfonic Acid Derivative and Its Application in Drug Therapy

专利号:CN-115197851-A
优先权日:2022-05-30
标题:Penicillium difficile and its use in regulating the synthesis of tanshinones in the roots of Salvia miltiorrhiza