CAS: 57591-61-4; (R)-Methyl 2-Amino-2-(4-Hydroxyphenyl)Acetate Hydrochloride

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methanol D-4-hydroxyphenylglycine D-2-p-hydroxyphenylglycine methyl ester amoxicillin N-(2-methylcinnamylidene)-α-p-hydroxyphenylglycine methyl ester (R)-N-[α-(methoxycarbonyl)-4-hydroxybenzyl]-2-phenylquinoline-4-carboxamide (R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetate methyl ester

左旋对羟基苯甘氨酸甲酯置于氯化亚砜体系中,用 甲醇 作为反应溶剂,化学反应 17.0H,以100%的收率获得产物d-对羟基苯甘氨酸甲酯盐酸盐
参考文献:一种rorγ抑制剂的中间体及其制备方法
标题:一种rorγ抑制剂的中间体及其制备方法
摘要:本发明属于药物技术领域,具体涉及一种rorγ抑制剂的中间体及其制备方法,所述中间体如下式(I)所示,该方法具有原料易得,工艺简洁,经济环保,收率高等优点.

专利信息

专利号:EP-2173892-B8
优先权日:2007-07-27
标题:Process for the preparation of immobilised recombinant Penicillin Acylase biocatalyst from Achromobacter sp CCM 4824 expressed in E. coli BL21 CCM 7394 and its use for the synthesis of beta-lactam antiobiotics
发明人：DATLA ANUPAMA; RAJASEKAR VYASARAYANI WILLIAMS; KYSLIK PAVEL; BECKA STANISLAV; KRISHNAKANT ASHAR TRUPTI; YOGESH ZAMBRE SUJATA; NIKUNJ KUMAR
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.

专利号:KR-20100072171-A
优先权日:2007-07-27
标 题:this. Method for the preparation of an immobilized recombinant penicillin acylase catalyst derived from Acromobacter sp. CMC 4824 expressed in E. coli LL 21 CCM 7394 and its use for the synthesis of beta-lactam antibiotics

专利号:WO-2009016642-A1
优先权日:2007-07-27
标题 :Process for the preparation of immobilized recombinant penicillin acylase catalyst from achromobacter sp. ccm 4824 expressed in e. coli bl 21 ccm 7394 and its use for the synthesis of beta-lactam antibiotics

专利号:US-2010190206-A1
优先权日:2007-07-27
标 题:Process for the preparation of immobilized recombinant penicillin acylase catalyst from achromobacter sp. ccm 4824 expressed in e. coli bl 21 ccm 7394 and its use for the synthesis of beta-lactam antibiotics

专利号:RU-2108342-C1
优先权日:1990-06-18
标题:Cyclopeptide or its pharmaceutically acceptable salt, methods of synthesis and pharmaceutical composition