CAS: 996-35-0; N,N-Dimethylpropan-2-Amine

该化合物是第三级分子式C5H13N的汞,其特点是清晰,无色液体形式和浓厚的氨气味,是有机合成的多用途中间体,特别是在制药,农用化学品和特殊化学品的生产方面.其主要优势包括作为基底或核分裂剂的高回活动性,促进高效的对流和相互碰撞反应.该化合物的低沸点和普通有机溶剂溶解性增强了其在工业工艺中的用途.由于易燃性和腐蚀性,适当的处理是必不可少的.在典型的储存条件下,其稳定性确保了合成应用的可靠性能.

结构式图片

相似化合物

4747-21-1 14610-37-8 4151-44-4

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

methyl magnesium iodide α-(dimethylamino)-propionitrile formaldehyd isopropylamine hydr°Chlorideformaldehyd N-methylpropan-2-amine 3,3,4-Trimethyl-1,2,2-trifluor-1-chlor-4-azapentan 4,5-Dimethyl-1,2,2-trifluor-1-chlor-4-azahexan

合成工艺路线路线简述

    在 氢氧化钾体系中,用 甲醇 作为反应溶剂,化学反应 0.5H,反应生成 N,N-二甲基异丙胺
    参考文献:乙醛 N-烷基-N,N-二甲基腙盐的碱促进消除反应.n,N-二甲基烷基胺的简便合成
    标题:乙醛 N-烷基-N,N-二甲基腙盐的碱促进消除反应.n,N-二甲基烷基胺的简便合成
    摘要:摘要 标题反应用于将 Sn2 反应性烷基卤有效转化为相应的 N,N-二甲基烷基胺.
    DOI:10.1080/00397919208055415

    海关参考信息

    专利信息


    专利号:US-9353057-B2
    优先权日:2003-12-30
    标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
    权利人:XENOPORT INC
    摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

    专利号:US-10696622-B2
    优先权日:2016-08-29
    标题 :Synthesis of N-vinyl carboxylic acid amides
    发明人:DUMOLEIJN KIM; MOONEN KRISTOF; Henricot Alexis; Han Cai Xing Simon
    权利人:TAMINCO BVBA; EASTMAN CHEM CO
    摘要:Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.

    专利号:WO-0140193-A1
    优先权日:1999-12-03
    标题:Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-6951932-B2
    优先权日:2001-10-25
    标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
    发明人:MOORMAN ALLAN R
    权利人:KING PHARMACEUTICALS RES & DEV
    摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.

    专利号:US-7423169-B2
    优先权日:2001-06-11
    标 题:Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
    发明人:RAILLARD STEPHEN P; ZHOU CINDY X; YAO FENMEI; MANTHATI SURESH KUMAR; XIANG JIA-NING; GALLOP MARK A
    权利人:XENOPORT INC
    摘要:The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.

    专利号:US-7777023-B2
    优先权日:1998-10-23
    标题 :Method for the chemical synthesis of oligonucleotides
    发明人:VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN
    权利人:SIRNA THERAPEUTICS INC
    摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.
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    合成参考文献


    摘要:Tian, T.; Li, Z., Science of Synthesis Knowledge Updates, (2020) 2, 376.
    摘要:Li, X.; Song, Q., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 324.
    参考文献:10.1107/s1600536810047914
    摘要:Jin RF, Yu K, Yang SY, Huang RB. 10H-Phenothia-zine 5-oxide. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 24;66(Pt 12):o3267.
    参考文献:10.1021/jp062539a
    摘要:Minitti MP, Cardoza JD, Weber PM. Rydberg fingerprint spectroscopy of hot molecules: structural dispersion in flexible hydrocarbons. J Phys Chem A. 2006 Aug 31;110(34):10212–8. doi: 10.1021/jp062539a.
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