CAS: 120747-84-4; 2-Aminopyrimidine-5-Carbaldehyde

相似化合物

308348-93-8 57401-76-0 3167-50-8

上下游产品

triformylmethane guanidine hydr°Chloride guanidine hydrogen carbonate 2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate 2-aminopyrimidine-5-carbaldehyde phenylhydrazone (2-aminopyrimidin-5-yl)methanol 5H6N4°C5H6N4O

2-氨基吡啶-5-羧酸甲酯置于水,Lithium Hydroxide,盐酸体系中,用 甲醇,水 用作溶剂,以90%的收率获得2-氨基-5-嘧啶甲醛
参考文献: Aminoalcohol Substituted 2,3-Dihydroimidazo[1,2-C]Quinazoline Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis[fr] Dérivés De 2,3-Dihydroimidazo[1,2-C]Quinazoléine Substitués Par Un Aminoalcool Utiles Pour Traiter Des Troubles Hyperprolifératifs Et Des Maladies Associées à L'Angiogenèse
标题: Aminoalcohol Substituted 2,3-Dihydroimidazo[1,2-C]Quinazoline Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis[fr] Dérivés De 2,3-Dihydroimidazo[1,2-C]Quinazoléine Substitués Par Un Aminoalcool Utiles Pour Traiter Des Troubles Hyperprolifératifs Et Des Maladies Associées à L'Angiogenèse
摘要:这项发明涉及新颖的2,3-二氢咪唑[1,2-C]喹唑啉化合物,包含这些化合物的药物组合物以及利用这些化合物或组合物进行磷脂酰肌醇-3-激酶(pi3K)抑制和治疗与磷脂酰肌醇-3-激酶(pi3K)活性相关的疾病,特别是治疗高增殖和/或血管生成障碍,作为唯一药剂或与其他活性成分组合使用.

专利信息

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.