CAS: 146982-24-3; Fmoc-Asp(Oall)-Oh

相似化合物

177609-12-0 132286-77-2 144120-53-6

上下游产品

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (S)-4-(allyloxy)-2-amino-4-oxobutanoic acid hydr°Chloride 25H25NO6C25H25NO6(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-allyl ester 1-(1-methyl-1-phenyl-ethyl) ester (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-(1-methyl-1-phenyl-ethyl) ester (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester 1-(1-methyl-1-phenyl-ethyl) ester

Fmoc-Asp-(Oall)-Oh置于alcalase-Cross-Linked-Enzyme-Aggregates体系中,用 叔丁醇 用作溶剂,化学反应 16.0H,以77%的收率获得fmoc-L-天冬氨酸 4-烯丙酯
参考文献:A Versatile And Selective Chemo-Enzymatic Synthesis Of β-Protected Aspartic And γ-Protected Glutamic Acid Derivatives
标题:A Versatile And Selective Chemo-Enzymatic Synthesis Of β-Protected Aspartic And γ-Protected Glutamic Acid Derivatives
摘要:Two Versatile,High Yielding,And Efficient Chemo-Enzymatic Methods For The Synthesis Of Beta-Protected Asp And Gamma-Protected Glu Derivatives Using Alcalase Are Described. The First Method Is Based On The Alpha-Selective Enzymatic Hydrolysis Of Symmetrical Aspartyl And Glutamyl Diesters. The Second Method Involving Mixed Diesters Comprises A Three-Step Protocol Using (I) Alpha-Selective Enzymatic Methyl-Esterification,(II) Chemical Beta-Esterification,And Finally (III) Alpha-Selective Enzymatic Methyl Ester Hydrolysis. The Yields Of The Purified Beta-And Gamma-Esters Range From 77% To 91%. (C) 2009 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2009.03.130

专利信息

专利号:WO-2024261319-A1
优先权日:2023-06-23
标题 :Methods of chemical synthesis of peptides
发明人：AL MUSAIMI OTHMAN; WILLIAMS DARYL ROBERT
权利人:IMPERIAL COLLEGE INNOVATIONS LTD
摘要:The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.

专利号:DE-69218193-T2
优先权日:1991-04-25
标 题 :Process for the synthesis of peptides, derivatives of amino acids for use in the above process and methods for their preparation.

专利号:FR-2675804-A1
优先权日:1991-04-25
标题 :PROCESS FOR THE SYNTHESIS OF PEPTIDES, NEW DERIVATIVES OF AMINO ACIDS USED IN THIS PROCESS AND THEIR PREPARATION PROCESSES.

专利号:CN-113135979-A
优先权日:2020-01-18
标题 :A method for solid-phase synthesis of peptides

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.

专利号:CN-117088966-A
优先权日:2022-12-29
标题 :A kind of synthesis method of bivalirudin impurity